XANTHINURIA - AN INBORN ERROR (OR DEVIATION) OF METABOLISM
XANTHINURIA - AN INBORN ERROR (OR DEVIATION) OF METABOLISM
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DOI：
10.1016/s0140-6736(54)91257-x
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发表时间：
1954-01-01
期刊：
影响因子：
168.9
通讯作者：
PHILPOT, GR
中科院分区：
文献类型：
--
作者：
DENT, CE;PHILPOT, GR
测定了用促肾上腺皮质激素治疗的患者血浆和尿液中还原型抗坏血酸及其直接氧化产物的量。在抗坏血酸饱和度足够的患者中，尿量增加，通常是暂时的，这种增加可能是由于三个原因：抗坏血酸的肾清除率增加;抗坏血酸可能沿着水的通常转移而从细胞转移到细胞外液;以及另一种未被识别的机制导致抗坏血酸从细胞转移到细胞外液。在抗坏血酸饱和度足够的患者中，有证据表明抗坏血酸的直接氧化产物的产生增加。控制
The amounts of reduced ascorbic acid and its immediate oxidation products in the plasma and urine of patients treated with corticotrophin were determined. In patients with adequate ascorbic-acid saturation there was an increased urinary output, usually temporary.This increase was probably due to three causes: an increased renal clearance of ascorbic acid; a probable shift of ascorbic acid from cells to extracellular fluid along with the usual shift of water; and another unidentified mechanism causing an additional transfer of ascorbic acid from the cells to extracellular fluid. In patients with adequate ascorbic-acid saturation there was evidence for increased production of the immediate oxidation products of ascorbic acid. Control