Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes
Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes
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DOI：
10.1089/jmf.2016.0065
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发表时间：
2017-05-01
影响因子：
2.4
通讯作者：
Sweazea, Karen
中科院分区：
文献类型：
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作者：
Aslam, Farhan;Iqbal, Sanaullah;Sweazea, Karen
白色芝麻油（WSSO）已被用于烹饪和食品准备了几个世纪。它有许多据称的健康益处，可能是一种有前途的营养品。本研究的主要目的是检查WSSO对化学诱导的糖尿病雄性Sprague-Dawley大鼠的空腹血糖（GLU）和胰岛素（INS）的影响。第二个目的是探索其他血液学生物标志物的肝脏，心脏和肾功能。将63只雄性Sprague-Dawley大鼠随机分为标准饮食组、正常对照组（NCON）（n = 21）、糖尿病对照组（DCON）（n = 21）和糖尿病芝麻油组（DSO）（n = 21），这些组饲喂含12%WSSO的饮食。在第0、30和60天分析血样。采用双向重复测量方差分析评估组间和跨天差异。基线时，两个糖尿病组的Glu和INS相似，分别为平均248.4 +/- 2.8 mg/dL和平均23.4 +/- 0.4 mu U/mL。60天时，GLU显著高于对照组（P
White sesame seed oil (WSSO) has been used in cooking and food preparations for centuries. It has many purported health benefits and may be a promising nutraceutical. The primary purpose of this study was to examine the effects of WSSO on fasting blood glucose (GLU) and insulin (INS) in male Sprague-Dawley rats with chemically induced diabetes. A secondary aim was to explore other hematological biomarkers of hepatic, cardiac, and renal function. Sixty-three male Sprague-Dawley rats were randomized into standard diet groups, normal control (NCON) (n = 21) and diabetic control (DCON) (n = 21), and a diabetic sesame oil (DSO) (n = 21) group, which were fed a diet containing 12% WSSO. Blood samples were analyzed at 0, 30, and 60 days. Differences between groups and across days were assessed with two-way repeated measures analysis of variance. At baseline, GLUand INS were similar in both diabetic groups, mean 248.4 +/- 2.8 mg/dL and mean 23.4 +/- 0.4 mu U/mL, respectively. At 60 days, GLU was significantly (P