Stress reactivity and its effects on subsequent food intake in depressed and healthy women with and without adverse childhood experiences
Stress reactivity and its effects on subsequent food intake in depressed and healthy women with and without adverse childhood experiences
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有或没有不良童年经历的抑郁女性和健康女性的应激反应及其对随后食物摄入的影响
DOI：
10.1016/j.psyneuen.2017.03.014
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发表时间：
2017
影响因子：
3.7
通讯作者：
Spitzer
中科院分区：
文献类型：
--
作者：
Wingenfeld;Boeker;Schultebraucks;Ritter;Hellmann-Regen;Spitzer
背景相反的童年经历(ACE)会增加成年后患上严重抑郁障碍(MDD)、肥胖或代谢综合征的风险。此外，ACE可能与对压力的过度内分泌反应有关，这反过来可能导致食物摄入量增加，导致肥胖和代谢问题。方法我们系统地检测了32名通过临床访谈(早期创伤问卷)确定的MDD和ACE女性的应激反应和连续食物摄入，52名没有ACE的MDD女性，22名ACE但没有现在或终生MDD的女性和37名没有MDD或ACE的健康女性。所有参与者都接受了心理社会压力测试(Trier Social Stress Test，TSST)和对照条件(安慰剂-TSST)，然后给他们提供了自助餐。参与者不知道主要的结果变量是消耗的千卡路里(千卡)。结果四组在人口统计学变量上没有差异。与对照组相比，应激导致皮质醇释放增加，血压升高。与对照组相比，没有血管紧张素转换酶的MDD患者的皮质醇应激反应显著降低。在不同的人群中，我们发现压力后的卡路里摄入量比对照条件下更高。比较高皮质醇应答者和低皮质醇应答者，只有皮质醇释放量低的个体才会在应激后摄入更高的卡路里。结论本研究提供了证据表明，对应激反应钝化而不是增加皮质醇释放可能导致食物摄入量增加，这与MDD和ACE无关。
BackgroundAdverse childhood experiences (ACE) increase the risk to develop major depressive disorder (MDD) and obesity or metabolic syndrome in adulthood. In addition, ACE may be associated with an exaggerated endocrine response to stress, which, in turn, may lead to enhanced food intake resulting in obesity and metabolic problems.MethodsWe systematically examined the stress response and consecutive food intake in 32 women with MDD and ACE as determined by a clinical interview (Early Trauma Inventory), 52 women with MDD without ACE, 22 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE. All participants underwent a psychosocial stress test (Trier Social Stress Test, TSST) and a control condition (Placebo-TSST) before they were offered a buffet of snacks. Participants were not aware that the primary outcome variable was the amount of consumed kilocalories (kcal).ResultsThe four groups did not differ in demographic variables. Stress resulted in higher cortisol release and higher blood pressure compared to the control condition. Patients with MDD without ACE had a significantly lower cortisol response to stress compared to controls. Across groups, we found higher kcal intake after stress compared to the control condition. Comparing high and low cortisol responders to stress, higher kcal intake after stress was only seen in those with low cortisol release.ConclusionsThis study provides evidence that blunted rather than enhanced cortisol release to stress might lead to increased food intake, independent from MDD and ACE.
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相对缺乏症和高皮层化学既与抑郁症和躁郁症的生活质量较低有关：一项横断面研究。
影响因子：
3.7
作者：
Maripuu M;Wikgren M;Karling P;Adolfsson R;Norrback KF
通讯作者：
Norrback KF
皮质醇反应和痛苦引起的情绪饮食
影响因子：
3.7
作者：
T. Strien;K. Roelofs;C. Weerth
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C. Weerth
童年时期遭受心理创伤对精神疾病和躯体不适风险的影响：单一与多种类型的心理创伤
影响因子：
11.3
作者：
Subin Park;J. Hong;J. Bae;Seong;Dong;Jun;S. Chang;H. Jeon;B. Hahm;Young Moon Lee;S. Seong;M. Cho
通讯作者：
M. Cho
影响因子：
3.3
作者：
Peeters, F;Nicholson, NA;Berkhof, J
通讯作者：
Berkhof, J
德国版“早期创伤量表”(ETI) Erste Psychometrische Charakterisierung eines Interviews zur Erfassung Traumatischer Lebensereignisse in der Kindheit und Jugend
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
Katja Wingenfeld;M. Driessen;Christoph Mensebach;Nina Rullkoetter;Camille Schaffrath;C. Spitzer;Nicole Schlosser;T. Beblo;C. Heim
通讯作者：
C. Heim