Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function.
Three Types of Cortical Layer 5 Neurons That Differ in Brain-wide Connectivity and Function.
复制标题
DOI：
10.1016/j.neuron.2015.11.002
复制
发表时间：
2015-12-16
期刊：
影响因子：
16.2
通讯作者：
Callaway EM
中科院分区：
文献类型：
--
作者：
Kim EJ;Juavinett AL;Kyubwa EM;Jacobs MW;Callaway EM
皮质第 5 层 (L5) 锥体神经元整合来自多个来源的输入，并将输出分配给皮质和皮质下结构。先前的研究证明了两种 L5 金字塔类型：皮质-皮质 (CC) 和皮质-皮质下 (CS)。我们表征了小鼠初级视觉皮层中这些细胞类型的连接性和功能，并揭示了一种新的亚型。与之前描述的 L5 CC 和 CS 神经元不同，这种新亚型不会投射到纹状体 [皮质-皮质，非纹状体 (CC-NS)]，并且具有独特的形态、生理和视觉反应。单突触狂犬病追踪显示，CC 神经元优先接收来自较高视觉区域的输入，而 CS 神经元则从涉及大脑状态自上而下调节的结构接收更多输入。 CS 神经元也比 CC 神经元更具方向选择性，并且更喜欢更快的刺激。这些差异表明作为专门输出通道的不同作用，CS 神经元整合信息并产生与运动控制更相关的反应，而 CC 神经元在视觉感知中更重要。
Cortical layer 5 (L5) pyramidal neurons integrate inputs from many sources and distribute outputs to cortical and subcortical structures. Previous studies demonstrate two L5 pyramid types: cortico-cortical (CC) and cortico-subcortical (CS). We characterize connectivity and function of these cell types in mouse primary visual cortex and reveal a new subtype. Unlike previously described L5 CC and CS neurons, this new subtype does not project to striatum [cortico-cortical, non-striatal (CC-NS)] and has distinct morphology, physiology and visual responses. Monosynaptic rabies tracing reveals that CC neurons preferentially receive input from higher visual areas, while CS neurons receive more input from structures implicated in top-down modulation of brain states. CS neurons are also more direction-selective and prefer faster stimuli than CC neurons. These differences suggest distinct roles as specialized output channels, with CS neurons integrating information and generating responses more relevant to movement control and CC neurons being more important in visual perception.