Long-term outcome of pediatric aphakic glaucoma
Long-term outcome of pediatric aphakic glaucoma
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DOI：
10.1016/j.jaapos.2006.01.005
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发表时间：
2006-06-01
期刊：
影响因子：
1.6
通讯作者：
Petersen, Danid B.
中科院分区：
文献类型：
--
作者：
Bhola, Rahul;Keech, Ronald V.;Petersen, Danid B.
目的：探讨儿童无晶状体型青光眼的远期疗效。方法：对1969~2004年间确诊的130例无晶状体青光眼患者进行回顾性分析。本研究共纳入36名患者(55只眼)，排除了10岁以后行白内障摘除术的患者，以及有其他眼部疾病、全身综合征、外伤性白内障、先天性青光眼或随访不足(不到1年)的患者。研究的结果变量包括视力、在随访过程中需要更换药物的次数、一次使用超过6个月的最大用药次数以控制眼压，以及需要手术干预。平均随访18.7年(6.9~35年)。结果：末次随访时，54.5%的患者视力在20/40以上，34.5%的患者视力在20/50~20/200之间，11%的患者视力低于20/200。在随访过程中，34%的患者需要更换1~2种药物来控制青光眼，33%的患者需要更换3~5种药物，33%的患者需要更换6种或更多的药物，36%的患者在随访过程中需要最多服用1~2种药物来控制眼压，33%的患者需要3种药物，31%的患者需要4种或更多的药物来控制眼压。在55只眼中，15只眼(27%)需要手术治疗，6只眼(40%)需要1次手术，8只眼(53%)需要2-3次手术，1只眼(7%)需要4-6次手术。结论：儿童白内障术后青光眼患者视力恢复良好，但仍需多种药物和手术干预。
Purpose: To determine the long-term outcome in pediatric patients with aphakic glaucoma. Methods: A retrospective analysis of 130 patients diagnosed with aphakic glaucoma between 1969 and 2004 was performed. A total of 36 patients (55 eyes) were included in this study after excluding those who had cataract extraction after age 10 and those patients with other ocular conditions, systemic syndromes, traumatic cataracts, congenital glaucoma, or inadequate follow-up (less than 1 year). Outcome variables studied included visual acuity, number of medication changes required over the course of the follow-up, maximum number of medications used at a time for more than 6 months to control intraocular pressures, and surgical interventions required. Mean follow-up period was 18.7 years (range, 6.9-35 years). Results: At the time of last follow-up, 54.5% of the patients had visual acuity 20/40 or better, 34.5% had 20/50 to 20/200, and 11 % had acuity worse than 20/200. During the course of follow-up, 34% required 1 to 2 medication changes for controlling glaucoma, 33% required 3 to 5 medication changes, and 33% required 6 or more medication changes, Thirty-six percent of the eyes required a maximum of 1 to 2 medications for more than 6 months during the course of follow-up, 33% required 3, and 31% required 4 or more medications for controlling intraocular pressure. Of the 55 eyes, 15 eyes (27%) required surgical intervention, Six of the 15 eyes (40%) required 1 surgery, 8 eyes (53%) required 2 to 3 surgeries, and 1 eye (7%) required 4 to 6 surgeries. Conclusion: Patients with glaucoma after pediatric cataract surgery can have a good visual outcome although multiple medications and surgical interventions may be required to control the glaucoma.