Illuminating the physiology of extracellular vesicles.
Illuminating the physiology of extracellular vesicles.
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DOI：
10.1186/s13287-016-0316-1
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发表时间：
2016-04-16
影响因子：
7.5
通讯作者：
Lee DS
中科院分区：
文献类型：
--
作者：
Choi H;Lee DS
细胞外囊泡通过将生物物质从供体细胞传递到受体细胞，在细胞间通讯中起着至关重要的作用。它们在癌症转移、神经退行性疾病和炎症中具有病理生理作用。细胞外囊泡也显示出作为新兴治疗剂的前景，理解其生理学，包括靶向，分布和清除，因此成为一个重要的问题。在这里，我们回顾了最近的进展，在体内跟踪和成像细胞外囊泡的方法，并严格讨论其全身分布，靶向和动力学的基础上，最新的证据在文献中。
Extracellular vesicles play a crucial role in intercellular communication by transmitting biological materials from donor cells to recipient cells. They have pathophysiologic roles in cancer metastasis, neurodegenerative diseases, and inflammation. Extracellular vesicles also show promise as emerging therapeutics, with understanding of their physiology including targeting, distribution, and clearance therefore becoming an important issue. Here, we review recent advances in methods for tracking and imaging extracellular vesicles in vivo and critically discuss their systemic distribution, targeting, and kinetics based on up-to-date evidence in the literature.