A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
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DOI：
10.1016/j.ccr.2009.12.049
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发表时间：
2010-04-13
期刊：
影响因子：
50.3
通讯作者：
Phillips, Heidi S.
中科院分区：
文献类型：
--
作者：
Chen, Ruihuan;Nishimura, Merry C.;Phillips, Heidi S.
据报道，神经干细胞标志物CD 133可以识别胶质母细胞瘤（GBM）中可以启动神经球生长和肿瘤形成的细胞;然而，也有报道称CD 133（-）细胞表现出类似特性。在这里，我们发现一些PTEN缺陷的GBM肿瘤产生一系列的CD 133（+）和CD 133（-）自我更新的肿瘤起始细胞类型，并提供证据表明，这些细胞类型构成了谱系层次。我们的研究结果表明，GBM的自我更新和肿瘤发生的能力不需要局限于一个统一的干细胞样细胞群体，但可以共享的自我更新细胞类型的谱系表达的前脑谱系的一系列标志物。
The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133(+) and CD133(-) self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.