Translating cell polarity into tissue elongation.
Translating cell polarity into tissue elongation.
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DOI：
10.1016/j.semcdb.2011.09.013
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发表时间：
2011-10
影响因子：
7.3
通讯作者：
Zallen JA
中科院分区：
文献类型：
--
作者：
Vichas A;Zallen JA
平面细胞极性，即多细胞组织平面内单细胞不对称的方向，对于生成器官和生物体的形状和尺寸至关重要。平面极性系统使细胞行为与身体轴保持一致，并定向导致组织伸长的细胞过程。使用果蝇作为模型系统，在理解生化和机械信号如何产生平面极性方面取得了重大进展。最近使用延时成像的研究表明，细胞从事许多主动行为，其方向和动力学将平面细胞极性转化为组织伸长。在这里，我们回顾了理解将平面极性与组织结构大规模变化联系起来的细胞机制的最新进展。
Planar cell polarity, the orientation of single-cell asymmetries within the plane of a multicellular tissue, is essential to generating the shape and dimensions of organs and organisms. Planar polarity systems align cell behavior with the body axes and orient the cellular processes that lead to tissue elongation. Using Drosophila as a model system, significant progress has been made toward understanding how planar polarity is generated by biochemical and mechanical signals. Recent studies using time-lapse imaging reveal that cells engage in a number of active behaviors whose orientation and dynamics translate planar cell polarity into tissue elongation. Here we review recent progress in understanding the cellular mechanisms that link planar polarity to large-scale changes in tissue structure.