A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp.
A comparison of traditional diarrhoea measurement methods with microbiological and biochemical indicators: A cross-sectional observational study in the Cox's Bazar displaced persons camp.
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DOI：
10.1016/j.eclinm.2021.101205
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发表时间：
2021-12
影响因子：
15.1
通讯作者：
Lilford R
中科院分区：
文献类型：
--
作者：
Rego R;Watson S;Alam MAU;Abdullah SA;Yunus M;Alam IT;Chowdhury ASMHK;Haider SMA;Faruque A;Khan AI;Hofer T;Gill P;Islam MS;Lilford R
水、环境卫生和个人卫生 (WASH) 系统旨在减少肠道病原体的传播，特别是在五岁以下儿童中。 WASH 试验最常见的主要结果是护理人员报告的腹泻。我们评估不同的腹泻调查工具作为粪便中肠道病原体存在的代理标记。我们从孟加拉国考克斯巴扎尔流离失所者营地招募了 800 名社区参与者，他们平均分配在雨季（2020 年 7 月/8 月）和旱季（2020 年 11 月/12 月）。参与者被均匀地随机分配到一项标准调查中，询问护理人员他们五岁以下的孩子在过去两周内是否腹泻过，或者进行一项图片调查，要求护理人员从图表中挑选五岁以下孩子在过去两周内出现过的粪便情况。我们从 120 名随机子样本中收集了粪便。对粪便进行了目视检查，并检测了与肠道感染相关的蛋白质和 16 种肠道病原体。我们计算了每种调查类型、目视检查和蛋白质与肠道病原体存在相关的敏感性和特异性。肠道病原体存在标准调查的敏感性为0.49[95%CI:0.32,0.66]，特异性为0.65[0.41,0.85]。图片调查、目视检查和蛋白质也观察到类似的敏感性和特异性。虽然腹泻是临床实践中的一个重要体征，但在流行病学调查中，它似乎不能很好地代表粪便中肠道病原体的存在。当对肠道感染感兴趣时，应直接测量。该项目由美国国立卫生研究院改善贫民窟健康全球健康研究组 (16/136/87) 和华威大学资助。
Water, Sanitation, and Hygiene (WASH) systems aim to reduce the spread of enteric pathogens, particularly amongst children under five years old. The most common primary outcome of WASH trials is carer-reported diarrhoea. We evaluate different diarrhoea survey instruments as proxy markers of enteric pathogen presence in stool. We recruited 800 community-based participants from the Cox's Bazar Displaced Person's Camp in Bangladesh, split evenly between the rainy (July/August 2020) and dry (November/December 2020) periods. Participants were randomized evenly into either a standard survey asking carers if their child under five years old has had diarrhoea in the past fortnight, or a pictorial survey asking carers to pick from a pictorial chart which stools their child under five years old has had in the past fortnight. We collected stools from a random sub-sample of 120. Stools were examined visually, and tested for proteins associated with enteric infection and 16 enteric pathogens. We calculated sensitivities and specificities for each survey type, visual examination, and proteins with respect to enteric pathogen presence. The sensitivity of the standard survey for enteric pathogen presence was 0.49[95%CI:0.32,0.66] and the specificity was 0.65[0.41,0.85]. Similar sensitivities and specificities were observed for pictorial survey, visual inspection, and proteins. While diarrhoea is an important sign in clinical practice it appears that it is a poor proxy for enteric pathogen presence in stool in epidemiological surveys. When enteric infection is of interest, this should be measured directly. The project was funded by the National Institutes for Health Research Global Health Research Unit on Improving Health in Slums (16/136/87) and by the University of Warwick.
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影响因子：
4.5
作者：
Khan MN;Islam MM
通讯作者：
Islam MM
影响因子：
13.6
作者：
Korpe PS;Petri WA Jr
通讯作者：
Petri WA Jr
影响因子：
5.1
作者：
Bekkali, Noor;Hamers, Sofie L.;Benninga, Marc A.
通讯作者：
Benninga, Marc A.
影响因子：
2.4
作者：
Nyeko, Richard;Kalyesubula, Israel;Bachou, Hanifa
通讯作者：
Bachou, Hanifa
DOI：
10.1016/s0924-8579(00)00293-4
发表时间：
2000-12-01
影响因子：
10.8
作者：
Bergogne-Bérézin, E
通讯作者：
Bergogne-Bérézin, E