DISTURBED PLANUM TEMPORALE ASYMMETRY IN SCHIZOPHRENIA - A QUANTITATIVE POSTMORTEM STUDY
DISTURBED PLANUM TEMPORALE ASYMMETRY IN SCHIZOPHRENIA - A QUANTITATIVE POSTMORTEM STUDY
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DOI：
10.1016/0920-9964(94)00035-7
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发表时间：
1995-01-01
影响因子：
4.5
通讯作者：
OVARY, I
中科院分区：
文献类型：
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作者：
FALKAI, P;BOGERTS, B;OVARY, I
对24例精神分裂症患者和24例年龄、性别匹配的对照组进行了死后颞叶皮质平面的研究。精神分裂症患者左侧颞平面体积缩小20%(p=0.032)，而男性患者右侧有增加趋势(+22%，p=0.17)，女性患者则呈中度缩小(-6%，p=0.74)。左侧颞平面前后径明显缩小(-20%，p=0.008)，右侧无明显变化。不对称系数(Galaburda等人)精神分裂症患者和正常对照组的颞叶平面皮质体积(p=0.02)和前后径(p=0.002)有显著差异，而平均面积(p=0.61)则无显著差异。这些数据支持精神分裂症患者大脑偏侧障碍的观点。对方法学和患者样本的含义进行了讨论。
The planum temporale of the temporal cortex was investigated post-mortem in 24 schizophrenic patients and 24 age- and sex-matched control subjects. Schizophrenic patients demonstrated a 20% volume reduction of the left planum temporale (p=0.032), whereas on the right side, there was a trend for increase in male schizophrenics (+22%, p=0.17), while in female patients the volume was moderately decreased (-6%, p=0.74). The mean anterior-posterior diameter of the planum temporale was significantly reduced in the left hemisphere (-20%, p=0.008), but unchanged on the right side. The asymmetry coefficients (Galaburda et al. (1987) Neuropsychologia 25, 853-868) for the planum temporale cortex volume (p=0.02) and anterior-posterior diameter (p=0.002) but not for mean area (p=0.61) were significantly different between schizophrenics and control subjects. These data support the idea of disturbed cerebral laterality in schizophrenia. The implications of methodology and patient samples are discussed.