Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
Distinguishing severe asthma phenotypes: Role of age at onset and eosinophilic inflammation
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DOI：
10.1016/j.jaci.2003.10.041
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发表时间：
2004-01-01
影响因子：
14.2
通讯作者：
Wenzel, SE
中科院分区：
文献类型：
--
作者：
Miranda, C;Busacker, A;Wenzel, SE
背景资料：哮喘是一个异质性的过程，但很少有人了解关于phenotypes.Objective：为了确定是否存在表型差异早发性，严重的哮喘与晚发性疾病相比，是否存在或不存在嗜酸性粒细胞影响的phenotypes.Methods：横断面分析综合临床，生理和病理数据收集80例严重哮喘。根据肺嗜酸性粒细胞的存在与否，将受试者分为12岁以前（n = 50）和12岁以后（n = 30）的哮喘发作组。
Background: Asthma is a heterogeneous process, yet little is understood regarding phenotypes.Objective: To determine whether phenotypic differences exist between early-onset, severe asthma as compared with late-onset disease and whether the presence or absence of eosinophilia influences the phenotypes.Methods: Cross-sectional analysis of integrated clinical, physiologic, and pathologic data collected from 80 subjects with severe asthma. Subjects were divided into those with asthma onset before age 12 years (n = 50) versus after age 12 (n = 30) and by the presence or absence of lung eosinophils.Results: Subjects with early-onset, severe asthma had significantly more allergen sensitivity (skin test positivity, 98% vs 76%, P