COMPARISON OF POLYATOMIC AND ATOMIC PRIMARY BEAMS FOR SECONDARY ION MASS-SPECTROMETRY OF ORGANICS
COMPARISON OF POLYATOMIC AND ATOMIC PRIMARY BEAMS FOR SECONDARY ION MASS-SPECTROMETRY OF ORGANICS
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DOI：
10.1021/ac00185a009
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发表时间：
1989-05-15
影响因子：
7.4
通讯作者：
DELMORE, JE
中科院分区：
文献类型：
--
作者：
APPELHANS, AD;DELMORE, JE
用SFe ~（0+）分子与8 keV Cs ~+离子束对常见有机药物样品进行了比较。两个光束都在静态西姆斯模式（plcoampere电流）下操作，样品在金属基底上的量从微克到亚纳克不等。对药物分子离子峰（+ H）+的效率（次级离子峰强度/初级束强度），分子初级束比原子初级束高9 ~ 24倍。这种效率差异反映在最小可检测样品质量上，对于分子束，最小可检测样品质量低2至20倍。
SFe0,~ molecules was compared with that of an 8-keV Cs+ atomic Ion beamfor samples of common organic pharmaceuticals. Both beams were operated In the static SIMS mode (plcoampere currents) and samples ranged from microgram to subnanogram quantities on metal substrates. The efficiency (secondary Ion peak Intenslty/prlmary beam in-tensity) for the molecular Ion peaks (+ H)+ of the pharmaceuticals was a factor of 9 to 24 higher for the molecular primary beam than for the atomic primary beam. This efficiency difference was reflected in the minimum detectable sample mass, which was a factor of 2 to 20 lower for the molecular beam.