Neuroanatomical changes in a mouse model of early life neglect
Neuroanatomical changes in a mouse model of early life neglect
复制标题
DOI：
10.1007/s00429-011-0350-9
复制
发表时间：
2012-04-01
影响因子：
3.1
通讯作者：
Simen, Arthur A.
中科院分区：
文献类型：
--
作者：
Duque, Alvaro;Coman, Daniel;Simen, Arthur A.
使用基于早期断奶的母体分离的新型早期生活忽视和虐待（ENA）小鼠模型，乔治等人（BMC Neurosci 11：123，2010）证明了成年小鼠的行为异常，而Bordner等人（Front Psychiatry 2（18）：1-18，2011）描述了mRNA和蛋白质表达的伴随变化。使用相同的模型，在这里，我们报告神经解剖学的变化，包括较小的大脑大小和异常的半球间不对称，皮质厚度减少，皮质下结构异常，和白色物质紊乱和萎缩最严重的影响左半球。由于在我们的小鼠模型中观察到的神经解剖学变化与在ENA的人类幸存者中描述的神经解剖学变化之间的相似性，这种新的动物模型对于在灵长类动物中进行的人类ENA的研究过于昂贵或繁琐可能是有用的。此外，我们目前对小鼠基因组的了解使得该模型特别适合于在其他物种中尚不可能进行的靶向解剖学、分子和药理学实验。
Using a novel mouse model of early life neglect and abuse (ENA) based on maternal separation with early weaning, George et al. (BMC Neurosci 11:123, 2010) demonstrated behavioral abnormalities in adult mice, and Bordner et al. (Front Psychiatry 2(18):1-18, 2011) described concomitant changes in mRNA and protein expression. Using the same model, here we report neuroanatomical changes that include smaller brain size and abnormal inter-hemispheric asymmetry, decreases in cortical thickness, abnormalities in subcortical structures, and white matter disorganization and atrophy most severely affecting the left hemisphere. Because of the similarities between the neuroanatomical changes observed in our mouse model and those described in human survivors of ENA, this novel animal model is potentially useful for studies of human ENA too costly or cumbersome to be carried out in primates. Moreover, our current knowledge of the mouse genome makes this model particularly suited for targeted anatomical, molecular, and pharmacological experimentation not yet possible in other species.