THE ROLE OF NMDA RECEPTOR SYSTEMS IN NEUROPEPTIDE RESPONSES TO STIMULANTS OF ABUSE
THE ROLE OF NMDA RECEPTOR SYSTEMS IN NEUROPEPTIDE RESPONSES TO STIMULANTS OF ABUSE
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DOI：
10.1016/0376-8716(94)01065-s
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发表时间：
1995-02-01
影响因子：
4.2
通讯作者：
GIBB, JW
中科院分区：
文献类型：
--
作者：
HANSON, GR;SINGH, N;GIBB, JW
大剂量滥用兴奋剂，如甲基苯丙胺和可卡因，会导致大鼠纹状体和伏隔核中神经紧张和啡肽样免疫反应性的含量显著增加（约为对照组的200-600%）。这些神经肽含量的变化是由多巴胺D-1受体的刺激引起的，并由谷氨酸NMDA受体拮抗剂MK 801阻止。n -甲基- d -天冬氨酸对NMDA受体的刺激会导致神经肽水平的增加，就像甲基苯丙胺和可卡因引起的那样。这些发现表明，滥用兴奋剂通过激活多巴胺D-1和谷氨酸NMDA受体的相互作用，深刻影响与锥体外系和边缘结构相关的神经紧张素和啡肽通路。
High doses of stimulants of abuse, such as methamphetamine and cocaine, cause significant increases in the content of neurotension- and dynorphin-like immunoreactivity in the striatum and nucleus accumbens (approximately 200-600% of control) in the rat. These changes in neuropeptide content are caused by stimulation of dopamine D-1 receptors and prevented by the glutamate NMDA receptor antagonist, MK 801. Stimulation of the NMDA receptor with N-methyl-D-aspartate results in increases in the neuropeptide levels like that caused by methamphetamine and cocaine. These findings demonstrate that stimulants of abuse profoundly influence neurotensin and dynorphin pathways associated with extrapyramidal and limbic structures by an interaction of activated dopamine D-1 and glutamate NMDA receptors.