Advanced application of magnetic resonance imaging in human brain science
Advanced application of magnetic resonance imaging in human brain science
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DOI：
10.1016/0387-7604(95)00090-9
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发表时间：
1995-11-01
影响因子：
1.7
通讯作者：
Bates, J
中科院分区：
文献类型：
--
作者：
Caviness, VS;Kennedy, DN;Bates, J
磁共振成像（MRI）已经彻底改变了临床神经病学的实际需求，这项技术现在有望在基础人脑科学的理论和应用领域中推进神经病学，我们在这里强调这些进展将发生的两个领域，第一个是人脑的体积形态测量，利用MRI，大脑的多个处理水平可以根据它们的绝对体积和它们的相对大小来表征，体积形态测量是我们理解神经系统发育和运作不可或缺的视角，也有望大幅提高神经学诊断的特异性和灵敏度，特别是当应用于结构异常仅反映在体积异常中的疾病时。这里考虑的第二个前进方向是MRI在支持认知神经科学的皮层映射中的应用。在该应用中，MRI提供了以高分辨率映射由行为范例激活的神经系统的子组件的分布的手段。这条研究路线将快速推进我们对大脑的信息处理算法如何映射到大脑的各种灰质结构的坐标上的理解，该应用的实际结果之一将是肿瘤和癫痫手术中手术野的合理设计。
Magnetic resonance imaging (MRI) has revolutionized the practical demands of clinical neurology, This technology promises now to advance neurology in theoretical and applied realms of fundamental human brain science, We emphasize here two domains in which these advances will occur, The first is volumetric morphometry of the human brain, With MRI the multiple levels of processing of the brain may be characterized in terms of their absolute volumes and their relative sizes, perspectives indispensable for our understanding of the development and operation of neural systems, Volumetric morphometry also promises substantial increases in the specificity and sensitivity of neurological diagnosis, particularly where applied to disorders where structural abnormalities will be reflected only in volumetric abnormalities. The second direction of advance considered here is application of MRI in cortical mapping in support of cognitive neuroscience. In this application MRI provides means to map at high resolution the distribution of subcomponents of neural systems activated by behavioral paradigms, This line of investigation will carry forward rapidly our understanding of how the information processing algorithms of the brain are mapped upon the coordinates of the various gray matter structures of the brain, Among the practical consequences of this application will be a reasoned design of surgical field in tumor and epilepsy surgery.