Genetic regulation of iron in Erwinia chrysanthemi as pertains to bacterial virulence
Genetic regulation of iron in Erwinia chrysanthemi as pertains to bacterial virulence
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DOI：
10.1007/1-4020-4743-6_10
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发表时间：
2006-01-01
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影响因子：
--
通讯作者：
Expert, Dominique
中科院分区：
文献类型：
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作者：
Expert, Dominique
植物是许多微生物的特权栖息地，因为它们是营养物质的主要来源。特别是，他们暴露于病原微生物，导致各种疾病，如果环境条件允许，这些疾病可能具有重要的经济意义。从生理和分子水平上阐明微生物毒力和植物免疫的机制，将有助于植物病害综合防治策略的发展。致病细菌产生毒力因子，使其能够获得营养物质并逃避宿主的防御。在这方面，病原体在宿主植物中获得铁的能力可能是一个重要的问题，因为这种金属是代谢所必需的，但在生物组织中不易获得。长期以来，铁一直被报道为细菌毒力和动物宿主防御的线索。这个问题一直是我们的研究工作的主要关注点，集中在软腐病所造成的欧文氏菌，病原体攻击广泛的农业重要植物。我们已经解决了不同的问题：什么是铁的收购和稳态机制参与E。在发病过程中，铁的可利用性是否作为毒力因子表达的触发信号？是否诱导了特定的植物反应，导致细菌在感染后缺铁？本章将阐述这些问题，并说明E。Chalcii使其铁代谢适应宿主中遇到的应激条件。
Plants represent privileged habitats for many microorganisms because they are a prime source of nutrients. In particular, they are exposed to pathogenic microorganisms causing a variety of diseases that may be economically important if environmental conditions are permissive. Elucidating the mechanisms of microbial virulence and plant immunity at the physiological and molecular levels should contribute to the development of integrative strategies for controlling plant diseases. A pathogenic bacterium produces virulence factors enabling it to gain access to nutrients and to escape host defenses. In this regard, the capacity of a pathogen to acquire iron in the host plant may be an important issue because this metal is essential for the metabolism but however not readily available in biological tissues. Iron has long been reported as a clue to bacterial virulence and animal host defense. This question has been a major concern of our research work focused on the soft rot disease caused by Erwinia chrysanthemi, a pathogen attacking a wide range of plants of agricultural importance. We have addressed different questions: what are the mechanisms of iron acquisition and homeostasis involved in E. chrysanthemi, during pathogenesis? Does iron availability act as a triggering signal for expression of virulence factors? Are specific plant reactions induced that lead to iron deprivation of the bacterium upon infection? This chapter illustrates these questions and shows how E. chrysanthemi adapts its iron metabolism to stressing conditions encountered in the host.