Kidney cancer in the Swedish family cancer database: Familial risks and second primary malignancics
Kidney cancer in the Swedish family cancer database: Familial risks and second primary malignancics
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DOI：
10.1046/j.1523-1755.2002.00304.x
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发表时间：
2002-05-01
影响因子：
19.6
通讯作者：
Hemminki, K
中科院分区：
文献类型：
--
作者：
Czene, KA;Hemminki, K
背景资料：肾癌的家族风险和与第二原发性恶性肿瘤的关联进行了研究，使用全国范围内的瑞典家庭CancerDatabase.Methods：癌症数据从瑞典癌症登记处检索1961年至1998年，包括23,137例肾癌。结果：共发现71个父母均患肾癌的家庭，其子女患肾癌的家庭危险度为1.56（1.22 ~ 1.95），人群归因比例为0.78%。患肾癌的兄弟姐妹患肾癌的风险相当高，SIR为4.72（2.28至9.20），可归因比例为0.77%。两代之间与肾癌相关的不一致肿瘤部位为中枢神经系统血管母细胞瘤。在兄弟姐妹中与肾癌相关的不一致的癌症部位是卵巢、内分泌腺和胰腺。在肾癌患者中，膀胱、神经系统和内分泌腺的第二原发恶性肿瘤增加了三倍以上。肾癌或家族性肾癌后第二次原发性血管母细胞瘤的危险度分别为21.19（6.69 ~ 43.83）和1206（114 ~ 3456）。结论：肾癌的兄弟姐妹危险度与子代危险度之比较高，可能反映了肾癌的隐性易感性。无家族史的患者中第二原发癌的高风险与多基因模型和不同程度的环境改变一致。
Background: Familial risks in kidney cancer and association with second primary malignancies were studied using the nationwide Swedish Family Cancer Database.Methods: Cancer data were retrieved from the Swedish Cancer Registry from years 1961 to 1998 and included 23,137 cases of kidney cancer. Standardized incidence ratios (SIRs) were used to measure the cancer risks.Results: Seventy-one families were identified where both a parent and an offspring had kidney cancer, giving a familial risk for offspring of 1.56 (1.22 to 1.95) and population attributable proportion of 0.78%. A risk for kidney cancer from an affected sibling was considerably higher with a SIR of 4.72 (2.28 to 9.20), giving an attributable proportion of 0.77%. The discordant tumor site that was associated with kidney cancer between two generations was hemangioblastoma of central nervous system. Discordant cancer sites that were associated with kidney cancer in siblings were ovaries, endocrine glands and pancreas. There was an over threefold increase of second primary malignancies of the urinary bladder, nervous system and endocrine gland in kidney cancer patients. The risks for second primary hemangioblastoma following kidney cancer or familial kidney cancer was 21.19 (6.69 to 43.83) and 1206 (114 to 3456), respectively.Conclusions: The high ratio of sibling risk to offspring risk in kidney cancer may reflect a recessive susceptibility. The high risk for second primary cancers in the patients without family history is consistent with a polygenic model and variable degree of environmental modification.