Platelet signaling: a complex interplay between inhibitory and activatory networks.
Platelet signaling: a complex interplay between inhibitory and activatory networks.
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DOI：
10.1111/jth.13302
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Gibbins JM
中科院分区：
文献类型：
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作者：
Bye AP;Unsworth AJ;Gibbins JM
血小板在止血和血栓形成中的作用取决于激活和抑制信号通路的复杂平衡。在没有血小板受体激动剂的情况下，从健康脉管系统释放的抑制信号抑制血小板活化。损伤部位存在的激活信号启动血小板激活和血栓形成;随后，内源性负信号调节剂抑制激活信号以控制血栓生长。了解激活和抑制信号网络之间的复杂相互作用是血小板生物学研究中的一个新挑战，需要一种系统的方法来有效地利用实验数据。在这篇综述中，我们将探讨血小板调节和信号传导的关键点，维持血小板处于静息状态，介导激活引发血栓形成，或提供负反馈。血小板信号传导将根据血小板激动剂激活的途径所共有的关键信号传导分子来描述，并且可以被描述为阳性和阴性调节剂的调节节点。
The role of platelets in hemostasis and thrombosis is dependent on a complex balance of activatory and inhibitory signaling pathways. Inhibitory signals released from the healthy vasculature suppress platelet activation in the absence of platelet receptor agonists. Activatory signals present at a site of injury initiate platelet activation and thrombus formation; subsequently, endogenous negative signaling regulators dampen activatory signals to control thrombus growth. Understanding the complex interplay between activatory and inhibitory signaling networks is an emerging challenge in the study of platelet biology, and necessitates a systematic approach to utilize experimental data effectively. In this review, we will explore the key points of platelet regulation and signaling that maintain platelets in a resting state, mediate activation to elicit thrombus formation, or provide negative feedback. Platelet signaling will be described in terms of key signaling molecules that are common to the pathways activated by platelet agonists and can be described as regulatory nodes for both positive and negative regulators.