Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.
Thalamocortical axons control the cytoarchitecture of neocortical layers by area-specific supply of VGF.
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DOI：
10.7554/elife.67549
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发表时间：
2022-03-15
期刊：
影响因子：
7.7
通讯作者：
Shimamura K
中科院分区：
文献类型：
--
作者：
Sato H;Hatakeyama J;Iwasato T;Araki K;Yamamoto N;Shimamura K
每个皮质层的神经元丰度和厚度都是每个区域特有的，但在发育过程中如何产生这种基本特征仍然知之甚少。虽然某些特定区域的特征是由内部线索，如形态发生素和转录因子控制的，但皮质外部线索，特别是丘脑轴突的确切影响和作用机制尚未完全建立。在这里，我们确定了丘脑衍生因子，VGF，这是必不可少的丘脑皮层轴突，以保持适量的第4层神经元在小鼠感觉皮层。这个过程是初级躯体感觉区进一步成熟的先决条件，例如由神经元活动依赖机制指导的桶场形成。我们的研究结果提供了一个实际的情况下，高度位点特异性的轴突投射赋予进一步的区域复杂性后，通过局部分泌信号分子从轴突终端的目标领域。
Neuronal abundance and thickness of each cortical layer are specific to each area, but how this fundamental feature arises during development remains poorly understood. While some of area-specific features are controlled by intrinsic cues such as morphogens and transcription factors, the exact influence and mechanisms of action by cues extrinsic to the cortex, in particular the thalamic axons, have not been fully established. Here, we identify a thalamus-derived factor, VGF, which is indispensable for thalamocortical axons to maintain the proper amount of layer 4 neurons in the mouse sensory cortices. This process is prerequisite for further maturation of the primary somatosensory area, such as barrel field formation instructed by a neuronal activity-dependent mechanism. Our results provide an actual case in which highly site-specific axon projection confers further regional complexity upon the target field through locally secreting signaling molecules from axon terminals.