Nonoscillatory Phase Coding and Synchronization in the Bat Hippocampal Formation
Nonoscillatory Phase Coding and Synchronization in the Bat Hippocampal Formation
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DOI：
10.1016/j.cell.2018.09.017
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发表时间：
2018-11-01
期刊：
影响因子：
64.5
通讯作者：
Ulanovsky, Nachum
中科院分区：
文献类型：
--
作者：
Eliav, Tamir;Geva-Sagiv, Maya;Ulanovsky, Nachum
海马theta振荡被认为对多种功能很重要，包括记忆和位置的时间编码。然而，以前的研究结果从蝙蝠提出质疑，这些建议报告缺乏θ节律在蝙蝠海马结构。这是否意味着时间编码是啮齿动物海马体所独有的，而不能推广到其他物种？在这里，我们报告说，令人惊讶的是，蝙蝠海马神经元确实表现出类似于啮齿动物的时间编码，尽管在1-20 Hz范围内没有任何连续的振荡。蝙蝠神经元表现出非常强的锁定场电位的非节律性波动，这样，尽管没有振荡，神经元还是同步在一起。此外，一些神经元表现出“相位进动”和蝙蝠位置的相位编码，当动物穿过位置场时，尖峰相位会更早地移动。这证明了哺乳动物大脑中一种意想不到的神经编码类型非振荡相位编码，并强调了跨物种海马功能同步和时间编码的重要性。
Hippocampal theta oscillations were proposed to be important for multiple functions, including memory and temporal coding of position. However, previous findings from bats have questioned these proposals by reporting absence of theta rhythmicity in bat hippocampal formation. Does this mean that temporal coding is unique to rodent hippocampus and does not generalize to other species? Here, we report that, surprisingly, bat hippocampal neurons do exhibit temporal coding similar to rodents, albeit without any continuous oscillations at the 1-20 Hz range. Bat neurons exhibited very strong locking to the non-rhythmic fluctuations of the field potential, such that neurons were synchronized together despite the absence of oscillations. Further, some neurons exhibited "phase precession'' and phase coding of the bat's position-with spike phases shifting earlier as the animal moved through the place field. This demonstrates an unexpected type of neural coding in the mammalian brain-nonoscillatory phase coding-and highlights the importance of synchrony and temporal coding for hippocampal function across species.