Vulnerability to smoking after trying a single cigarette can lie dormant for three years or more
Vulnerability to smoking after trying a single cigarette can lie dormant for three years or more
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DOI：
10.1136/tc.2005.014894
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发表时间：
2006-06-01
期刊：
影响因子：
5.2
通讯作者：
West, R.
中科院分区：
文献类型：
--
作者：
Fidler, J. A.;Wardle, J.;West, R.
目的：为了研究青少年吸烟行为的发展，在11岁时，曾尝试过一次香烟。设计：一个为期五年的前瞻性研究。设置：36所学校在南伦敦，England.Subjects：一个社会经济和种族多样化的学生样本完成问卷调查，每年从11-16岁。共有5863名学生参加了调查，年回复率为74- 85%。2041例（35%）提供了每年的吸烟状况数据。主要结果测量：目前吸烟（有时吸烟或更频繁）的第一次。可替宁检测提供了生化验证的吸烟status.Results：学生谁在11岁时曾尝试吸烟一次（n = 260），但不吸烟的时间，更有可能采取吸烟在以后的年龄比那些没有尝试吸烟（n = 1719），即使在长达三年的差距不吸烟。在14岁开始吸烟的几率是2.1倍（95%置信区间1.2至3.5），在11岁的“一次尝试”比“非尝试”，即使一旦性别，种族，剥夺，父母吸烟和行为disorder.Conclusions：这是第一次明确证明了“睡眠者效应”或休眠期的脆弱性。我们的研究结果对了解吸烟的发展和减少年轻人吸烟的政策具有重要意义。防止儿童尝试甚至一根香烟可能是重要的，干预措施的设计应该认识到青少年谁只吸了一次，几年前，作为潜在的脆弱性，以后吸烟的吸收。
Objective: To examine the development of smoking behaviour among adolescents who, at age 11, had tried cigarettes just once.Design: A five-year prospective study.Setting: 36 schools in South London, England.Subjects: A socioeconomically and ethnically diverse sample of students completed questionnaires annually from age 11-16. A total of 5863 students took part, with an annual response rate ranging from 74-85%. 2041 (35%) provided smoking status data every year.Main outcome measures: Current smoking ( smoking sometimes or more often) for the first time. Cotinine assays provided biochemical verification of smoking status.Results: Students who at age 11 reported having tried smoking cigarettes just once (n = 260), but were not smoking at the time, were more likely to take-up smoking at a later age than those that had not tried smoking ( n = 1719), even after a gap of up to three years of not smoking. The odds of starting to smoke at age 14 were 2.1 times greater (95% confidence interval 1.2 to 3.5) in the age 11 ''one time triers'' than the ''non-triers'', even once sex, ethnicity, deprivation, parental smoking and conduct disorder were adjusted for.Conclusions: This is the first clear demonstration of a ''sleeper effect'' or period of dormant vulnerability. Our findings have implications for understanding the development of cigarette use and for policies to reduce smoking in young people. Preventing children from trying even one cigarette may be important, and the design of interventions should recognise adolescents who have smoked just once, several years previously, as potentially vulnerable to later smoking uptake.