Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease.
Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease.
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DOI：
10.1016/j.immuni.2012.10.003
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发表时间：
2012-10-19
期刊：
影响因子：
32.4
通讯作者：
Artis D
中科院分区：
文献类型：
--
作者：
Sonnenberg GF;Artis D
哺乳动物的肠道中有数万亿有益的共生细菌，这些细菌对免疫系统的发育和多个器官的生理过程的维持至关重要。然而，人类的许多慢性感染性、炎症性和代谢性疾病都与共生菌的组成或定位改变有关，从而导致宿主-共生菌关系失调。哺乳动物的免疫系统在调节肠道中共生细菌群落的获取、组成和定位方面起着至关重要的作用。新兴研究表明，先天淋巴样细胞（ILCs）是一个关键的免疫细胞群，它协调了一些影响肠道免疫、炎症和组织稳态的宿主-共生关系。本文将讨论肠道共生菌和白细胞介素之间的相互作用在健康和疾病的背景下。
The mammalian intestine harbors trillions of beneficial commensal bacteria that are essential for the development of the immune system and for maintenance of physiologic processes in multiple organs. However, numerous chronic infectious, inflammatory and metabolic diseases in humans have been associated with alterations in the composition or localization of commensal bacteria that results in dysregulated host-commensal bacteria relationships. The mammalian immune system plays an essential role in regulating the acquisition, composition and localization of commensal bacterial communities in the intestine. Emerging research has implicated innate lymphoid cells (ILCs) as a critical immune cell population that orchestrates some of these host-commensal relationships that can impact immunity, inflammation and tissue homeostasis in the intestine. This review will discuss reciprocal interactions between intestinal commensal bacteria and ILCs in the context of health and disease.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
4.4
作者：
Fink, Lisbeth N.;Zeuthen, Louise H.;Ferlazzo, Guido
通讯作者：
Ferlazzo, Guido
影响因子：
32.4
作者：
Ganal, Stephanie C.;Sanos, Stephanie L.;Diefenbach, Andreas
通讯作者：
Diefenbach, Andreas
影响因子：
64.8
作者：
Bouskra, Djahida;Brezillon, Christophe;Eberl, Gerard
通讯作者：
Eberl, Gerard