Basal ganglia neural mechanisms of natural movement sequences
Basal ganglia neural mechanisms of natural movement sequences
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DOI：
10.1139/y04-061
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发表时间：
2004-08-01
影响因子：
2.1
通讯作者：
Rosen, AR
中科院分区：
文献类型：
--
作者：
Aldridge, JW;Berridge, KC;Rosen, AR
自然的啮齿动物梳理和其他本能行为作为复杂运动序列的自然模型。啮齿类动物的梳理有句法（规则驱动）序列和更随机的运动模式。两者都包含相同的动作，只是序列结构不同。背外侧纹状体和黑质网状部的神经活动记录表明，在句法序列中比在更随机的序列中更优先激活。在句法梳理序列中有反应的神经元通常在灵活或随机梳理序列中发生的运动学相似运动中没有反应或具有反向激活谱。很少有神经元可以被严格地归类为与运动相关——相反，它们只有在特定的连续运动模式下才会被激活。特定的顺序模式包括爪子、头部和身体运动的“句法链”梳理序列，以及“热身”序列，包括头部和身体/肢体运动，这些运动在安静休息一段时间后开始运动（Golani 1992）。与梳理序列相比，热身期间的激活强度和频率较低，但两种序列激活的神经元都高于基线水平，而且同一神经元有时对两种序列都有反应。纹状体神经元编码由不同组成运动组成的2种自然序列，这一事实表明基底神经节可能在序列控制中具有普遍作用。基底神经节受序列环境的调节，可能在复杂的自然序列行为模式中发挥执行功能。
Natural rodent grooming and other instinctive behavior serves as a natural model of complex movement sequences. Rodent grooming has syntactic (rule-driven) sequences and more random movement patterns. Both incorporate the same movements-only the serial structure differs. Recordings of neural activity in the dorsolateral striatum and the substantia nigra pars reticulata indicate preferential activation during syntactic sequences over more random sequences. Neurons that are responsive during syntactic grooming sequences are often unresponsive or have reverse activation profiles during kinematically similar movements that occur in flexible or random grooming sequences. Few neurons could be categorized as strictly movement related-instead they were activated only in the context of particular sequential patterns of movements. Particular sequential patterns included "syntactic chain" grooming sequences of paw, head, and body movements and also "warm-up" sequences, which consist of head and body/limb movements that precede locomotion after a period of quiet resting (Golani 1992). Activation during warm-up was less intense and less frequent than during grooming sequences, but both sequences activated neurons above baseline levels, and the same neurons sometimes responded to both sequences. The fact that striatal neurons code 2 natural sequences which are made up of different constituent movements suggests that the basal ganglia may have a generalized role in sequence control. The basal ganglia are modulated by the context of the sequence and may play an executive function in the complex natural patterns of sequenced behaviour.