Avian Influenza H6 Viruses Productively Infect and Cause Illness in Mice and Ferrets
Avian Influenza H6 Viruses Productively Infect and Cause Illness in Mice and Ferrets
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DOI：
10.1128/jvi.01206-08
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发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Subbarao, Kanta
中科院分区：
文献类型：
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作者：
Gillim-Ross, Laura;Santos, Celia;Subbarao, Kanta
流感大流行的防范工作重点关注流感病毒 H5 和 H7 亚型。然而，不可能准确预测哪种禽流感病毒亚型将导致下一次大流行，因此谨慎的做法是将其他禽流感病毒亚型纳入大流行防范工作中。 H6流感病毒被鉴定为1997年在香港出现的H5N1病毒的潜在祖先。该病毒继续在亚洲的鸟类中传播，其他H6病毒也在北美和亚洲的鸟类中流行。在流感病毒中观察到的高重配率和 H6 病毒在鸟类中的流行表明，这种亚型可能会造成大流行风险。对于哺乳动物中低致病性 H6 流感病毒的复制能力、免疫原性和保护性免疫的相关性，人们知之甚少。我们评估了 14 种 H6 流感病毒的抗原和遗传相关性及其在两种动物模型（小鼠和雪貂）中复制和诱导交叉反应免疫反应的能力。不同的H6病毒在小鼠和雪貂的呼吸道中复制到不同的水平，导致这两种模型出现不同程度的发病率和死亡率。 H6 病毒感染在小鼠和雪貂中诱导了类似的中和抗体反应模式；然而，观察到抗体反应的交叉反应性存在物种特异性差异。总体而言，H6 病毒感染小鼠中中和抗体的交叉反应性与针对异源野生型 H6 病毒的保护作用没有很好的相关性。然而，我们已经发现了一种 H6 病毒，它可以诱导针对北美和欧亚谱系病毒的保护性免疫力。
Influenza pandemic preparedness has focused on influenza virus H5 and H7 subtypes. However, it is not possible to predict with certainty which subtype of avian influenza virus will cause the next pandemic, and it is prudent to include other avian influenza virus subtypes in pandemic preparedness efforts. An H6 influenza virus was identified as a potential progenitor of the H5N1 viruses that emerged in Hong Kong in 1997. This virus continues to circulate in the bird population in Asia, and other H6 viruses are prevalent in birds in North America and Asia. The high rate of reassortment observed in influenza viruses and the prevalence of H6 viruses in birds suggest that this subtype may pose a pandemic risk. Very little is known about the replicative capacity, immunogenicity, and correlates of protective immunity for low-pathogenicity H6 influenza viruses in mammals. We evaluated the antigenic and genetic relatedness of 14 H6 influenza viruses and their abilities to replicate and induce a cross-reactive immune response in two animal models: mice and ferrets. The different H6 viruses replicated to different levels in the respiratory tracts of mice and ferrets, causing varied degrees of morbidity and mortality in these two models. H6 virus infection induced similar patterns of neutralizing antibody responses in mice and ferrets; however, species-specific differences in the cross-reactivity of the antibody responses were observed. Overall, cross-reactivity of neutralizing antibodies in H6 virus-infected mice did not correlate well with protection against heterologous wild-type H6 viruses. However, we have identified an H6 virus that induces protective immunity against viruses in the North American and Eurasian lineages.