The effects of combined selenium nanoparticles and radiation therapy on breast cancer cells in vitro
The effects of combined selenium nanoparticles and radiation therapy on breast cancer cells in vitro
复制标题
纳米硒联合放射治疗对体外乳腺癌细胞的影响
DOI：
10.1080/21691401.2017.1347941
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发表时间：
2018-01-01
影响因子：
5.8
通讯作者：
Zhang, Hai Qian
中科院分区：
文献类型：
--
作者：
Chen, Feng;Zhang, Xiao Hong;Zhang, Hai Qian
摘要放射增敏剂能增加癌细胞的放射敏感性，从而提高放射治疗的有效性，减少附带损害。纳米材料由于其独特的物理化学性质，已被用作放射增敏剂。在本文中，我们评估了硒纳米颗粒（Nano-Se）作为一种新的放射增敏剂。将纳米硒与照射结合用于MCF-7乳腺癌细胞，并评估这种联合治疗方法的疗效和机制。纳米硒增强了辐射的毒性作用，导致比单独使用的任何治疗更高的死亡率，诱导细胞周期停滞在G2/M期和自噬的激活，并增加内源性和辐射诱导的活性氧的形成。这些结果表明，纳米硒可以作为一种辅助药物，以提高癌细胞的敏感性，辐射的毒性作用，从而减少对周围正常组织的损害。
Abstract Radiosensitizers that increase cancer cell radio-sensitivity can enhance the effectiveness of irradiation and minimize collateral damage. Nanomaterial has been employed in conjunction with radiotherapy as radiosensitizers, due to its unique physicochemical properties. In this article, we evaluated selenium nanoparticles (Nano-Se) as a new radiosensitizer. Nano-Se was used in conjunction with irradiation on MCF-7 breast cancer cells, and efficacy and mechanisms of this combined treatment approach were evaluated. Nano-Se reinforced the toxic effects of irradiation, leading to a higher mortality rate than either treatment used alone, inducing cell cycle arrest at the G2/M phase and the activation of autophagy, and increasing both endogenous and irradiation-induced reactive oxygen species formation. These results suggest that Nano-Se can be used as an adjuvant drug to improve cancer cell sensitivity to the toxic effects of irradiation and thereby reduce damage to normal tissue nearby.