The regulatory network behind MHC class I expression
The regulatory network behind MHC class I expression
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DOI：
10.1016/j.molimm.2017.12.005
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发表时间：
2019-09-01
影响因子：
3.6
通讯作者：
Spaapen, Robbert M.
中科院分区：
文献类型：
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作者：
Jongsma, Marlieke L. M.;Guarda, Greta;Spaapen, Robbert M.
MHC I类途径将内源性衍生肽呈递给T淋巴细胞，在许多病理条件下被劫持。这影响MHC I类水平和细胞表面的肽呈递，导致癌细胞或微生物的免疫逃逸。因此，重要的是要确定背后的MHC I类表达，加工和抗原呈递的分子机制。NLRC 5作为MHC I类转录调节因子的鉴定是理解所涉及的转录机制的一个巨大进步。尽管如此，许多关于MHC I类转录的问题尚未解决。在这里，我们阐明了目前的知识MHC I类和NLRC 5转录，我们强调了一些剩余的问题，并讨论了使用快速开发的高内容筛选工具，以揭示在不久的将来在MHC I类转录的未知。
The MHC class I pathway, presenting endogenously derived peptides to T lymphocytes, is hijacked in many pathological conditions. This affects MHC class I levels and peptide presentation at the cell surface leading to immune escape of cancer cells or microbes. It is therefore important to identify the molecular mechanisms behind MHC class I expression, processing and antigen presentation. The identification of NLRC5 as regulator of MHC class I transcription was a huge step forward in understanding the transcriptional mechanism involved. Nevertheless, many questions concerning MHC class I transcription are yet unsolved. Here we illuminate current knowledge on MHC class I and NLRC5 transcription, we highlight some remaining questions and discuss the use of quickly developing high-content screening tools to reveal unknowns in MHC class I transcription in the near future.