Modular Automation Platforms: A Case Study of a Flexible NMR Sample Preparation Robot
Modular Automation Platforms: A Case Study of a Flexible NMR Sample Preparation Robot
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模块化自动化平台：灵活的 NMR 样品制备机器人案例研究
DOI：
10.1016/j.jala.2006.10.007
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
D. Davolos
中科院分区：
文献类型：
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作者：
Miguel A. Maccio;D. Bell;D. Davolos
本文介绍了本部门在自动化平台的设计和集成中所使用的各种功能。一个具有挑战性的项目，任何自动化组是自动化的核磁共振样品制备。将高挥发性或粘性溶液分配到典型的5毫米ID NMR玻璃管中，以及随后的管盖，提出了独特的问题。当使用10毫米蛋白质溶质时，角度增量单通道分配技术可防止气泡形成。一种新颖的夹具手指设计，与内部制造的聚四氟乙烯帽一起使用，可以可靠地覆盖核磁共振管。原位涡流最大限度地减少了小瓶处理，增加了吞吐量。磁性安装的机器人工具（手）提供精确的扣入定位与碰撞安全分离。这简化了开发测试和生产使用期间的崩溃恢复。具有模块化安全电路的环绕式安全外壳符合ANSI/RIA R15.06-1999安全要求。灵活的控制软件允许运行中断加载和准备额外的核磁共振管。在运行中断期间，准备好的样品可能会被移除。“飞越”条形码扫描工具使阳性化合物样品ID具有更高的吞吐量。通过开放式结构的仪器集成框架，预先存在的仪器控制软件方便地与调度应用程序接口。该框架允许开发自动化平台独立的中间件，以实现进度和分析的可移植性。新一代低功耗、轻便、便携和可扩展的平台也被展示出来，其中一个构建模块串联方法与机器人回收的Rent-a-robot概念相结合。
A variety of features used by our Department in the design and integration of Automation Platforms are presented here. A challenging project for any automation group is the automation of NMR sample preparation. The dispensing of highly volatile or viscous solutions into the typical 5 mm ID NMR glass tube, and the subsequent capping of the tube, presents unique problems. An angled incremental single-channel dispensing technique prevents bubble formation when a 10-mM protein—based solute is used. A novel gripper finger design, used in conjunction with in-house fabricated Teflon caps, allows reliable capping of NMR tubes. In situ vortexing minimizes vial handling with increased throughput. Magnetic mounting of robot tools (hands) provides precise snap-in positioning with collision-safe breakaway. This simplifies crash recovery during development testing and production use. A wraparound Safety Enclosure with modular safety circuit fulfills ANSI/RIA R15.06–1999 Safety Requirements. Flexible control software permits run interruption for loading and preparation of additional NMR tubes. Prepared samples may be removed during run interruption. A “Fly-By” barcode scanning tool enables positive compound sample ID with improved throughput. Preexisting instrument control software is conveniently interfaced to a Scheduler application through an open-architecture instrument integration framework. This framework allows the development of automation platform—independent Middleware for schedule and assay portability. A new generation of low-power, lightweight, portable and expandable platforms is also presented where a building block tandem approach is used in conjunction with the Rent-a-robot concept for robot recycling.