Enhanced therapeutic efficacy on lymph node metastasis by the use of peplomycin adsorbed on small activated carbon particles.
Enhanced therapeutic efficacy on lymph node metastasis by the use of peplomycin adsorbed on small activated carbon particles.
复制标题
通过使用吸附在小活性炭颗粒上的佩普霉素来增强对淋巴结转移的治疗效果。
作者：
A. Hagiwara;T. Takahashi;T. Ueda;A. Iwamoto;H. Yamashita;T. Maeda
在第0天，在左后爪的足垫对面皮下接种了5 × 105个MH 134肿瘤细胞的小鼠，在第10天，在左后爪的足垫中皮下注射0.25 mg/小鼠PEP-CH形式的培洛霉素（培洛霉素吸附在活性炭颗粒上）或培洛霉素水溶液。在第14天，将左侧腘淋巴结腹膜内转移至正常小鼠（受体）。与其他治疗组相比，PEP-CH组中受体的存活时间在统计学上显著延长，并且通过校准曲线估计的转移的肿瘤细胞数显著较小。
Mice into which 5 x 10(5) MH134 tumor cells had been inoculated subcutaneously opposite the foot-pad of the left hind paw on day 0, received subcutaneous injection of 0.25 mg/mouse of peplomycin in the form of PEP-CH (peplomycin adsorbed on activated carbon particles) or peplomycin aqueous solution into the foot-pad of the left hind paw on day 10. The left popliteal lymph nodes were transferred intraperitoneally to normal mice (the recipients) on day 14. In the PEP-CH group the survival time of the recipients was statistically significantly longer and the transferred tumor cell number estimated by calibration curve was markedly smaller in comparison with those in the other treatment groups.