Bone adaptation to load: microdamage,as a stimulus for bone remodelling
Bone adaptation to load: microdamage,as a stimulus for bone remodelling
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DOI：
10.1046/j.1469-7580.2002.00123.x
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发表时间：
2002-12-01
影响因子：
2.4
通讯作者：
Taylor, D
中科院分区：
文献类型：
--
作者：
Lee, TC;Staines, A;Taylor, D
近端桡骨的机械负荷通过尺骨截骨术（第 0 组）增加，通过斯坦曼钉扎（P 组）改变，或在 2-4 岁骨骼成熟雌性羊的假手术对照（C 组）中保持不变。给予一系列静脉内荧光染料来标记骨形成，并以长达 24 周的间隔评估品红染色的微损伤。所有组中均存在微裂纹，并在骨膜表面附近的原始皮质中发现。在骨膜或骨内膜表面放置的新纤维板层骨中没有发现微裂纹。平均微裂纹长度（49μm，SD 10μm）在组间或超时之间没有差异。所有组中的微裂纹数量和表面密度以及吸收腔密度在 6 周时达到峰值，与区域加速现象 (RAP) 一致，但 O 组的峰值明显更高。再充盈或继发骨的密度在 10 周时达到峰值，形成骨所需的平均时间为 7.51 +/- 0.59 周。疲劳引起的微损伤通常存在于骨骼中，并且由于机械超负荷的半径的重复负载而增加。微裂纹、吸收腔和次生骨的位置和时间与激活-吸收-形成重塑周期一致，表明微损伤是骨重塑的刺激因素。
Mechanical loading in the proximal radius was increased by ulnar osteotomy (Group 0), altered by Steinmann pinning (Group P) or unaltered in sham operated controls (Group C) in skeletally mature female sheep, aged 2-4 years. A series of intravenous fluorochromes were given to label bone formation and fuchsin-stained microdamage assessed at intervals of up to 24 weeks. Microcracks were present in all groups and were found in the original cortex near the periosteal surface. No microcracks were found in the new, fibrolamellar bone laid down at periosteal or endosteal surfaces. Mean microcrack length (49 mum, SD 10 mum) did not differ between groups or overtime. Microcrack numerical and surface densities and resorption cavity density peaked in all groups at 6 weeks, consistent with a regional acceleratory phenomenon (RAP), but the peaks were significantly greater in Group O. The density of refilling or secondary osteons peaked at 10 weeks and the mean time required for the formation of an osteon was 7.51 +/- 0.59 weeks. Fatigue-induced microdamage is normally present in bone and is increased due to repetitive loading of the mechanically overloaded radius. The location and timing of microcracks, resorption cavities and secondary osteons are consistent with the activation-resorption-formation remodelling cycle and suggest that microdamage is a stimulus for bone remodelling.