Bile cytology: A new scoring system for improving diagnostic accuracy.
Bile cytology: A new scoring system for improving diagnostic accuracy.
复制标题
胆汁细胞学：一种提高诊断准确性的新评分系统。
DOI：
10.1002/dc.24076
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发表时间：
2019
期刊：
影响因子：
1.3
通讯作者：
Koike J
中科院分区：
文献类型：
--
作者：
Hayakawa C;Hoshikawa M;Imura J;Ueno T;Koike J
背景：任何胆汁细胞学检查都需要区分良性和恶性细胞。在这里，我们报告一个原始的评分系统，以提高诊断的准确性胆汁细胞学。方法对158例胆汁抽取标本进行细胞学检查。14个细胞学结果被用来区分良性和恶性样本。统计显著性检验和多变量分析用于确定和量化显著发现，并制定评分系统。结果4种细胞学表现对良恶性细胞的鉴别具有重要意义：染色质异常、细胞核排列不规则、细胞核重叠不规则、团簇边缘不规则。我们新开发的基于这四种细胞学结果的评分系统获得了极好的结果，灵敏度为87%，特异性为98%，优势比为329。结论该评分系统的应用有望提高胆汁细胞学诊断的准确性。
BackgroundBenign and malignant cells need to be distinguished in any cytological examination of bile. Here, we report an original scoring system to improve the diagnostic accuracy of bile cytology.MethodsThe study used 158 bile aspiration samples obtained for cytological examination. Fourteen cytological findings were used to differentiate benign and malignant samples. Statistical significance tests and multivariate analysis were used to determine and quantify significant findings and develop a scoring system.ResultsFour cytological findings were significant in discriminating between benign and malignant cells: abnormal chromatin, irregularly arranged nuclei, irregularly overlapped nuclei, and irregular cluster margins. Our newly developed scoring system based on these four cytological findings yielded excellent results with a sensitivity of 87%, specificity of 98%, and an odds ratio of 329.ConclusionsThe use of our new scoring system is expected to contribute to the diagnostic accuracy of cytological evaluations of bile samples.