Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study
Is pulse pressure useful in predicting risk for coronary heart disease? The Framingham Heart Study
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DOI：
10.1161/01.cir.100.4.354
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发表时间：
1999-07-27
期刊：
影响因子：
37.8
通讯作者：
Levy, D
中科院分区：
文献类型：
--
作者：
Franklin, SS;Khan, SA;Levy, D
背景 - 目前高血压的定义基于收缩压（SBP）和舒张压（DBP）水平，而非脉压（PP）。我们在基于人群的弗雷明汉心脏研究中检验了脉压是否为预测冠心病（CHD）增添有用信息。
方法与结果 - 我们研究了基线时年龄在50到79岁之间的1924名男性和女性，他们没有冠心病的临床证据且未接受抗高血压药物治疗。通过对年龄、性别和其他风险因素进行校正的考克斯回归，用于评估在20年随访期间血压成分与冠心病风险之间的关系。当分别考虑每种压力时，收缩压、舒张压和脉压与冠心病风险呈正相关；在这三者中，脉压得出的卡方统计量最大。当收缩压和舒张压共同纳入多变量模型时，收缩压与冠心病风险呈正相关（风险比[HR]，1.22；95%置信区间[CI]，1.15 - 1.30），舒张压与冠心病风险呈负相关（HR，0.86；95%CI，0.75 - 0.98）。根据收缩压水平定义了四个亚组（
Background-Current definitions of hypertension are based on levels of systolic blood pressure (SBP) and diastolic blood pressure (DBP), but not on pulse pressure (PP). We examined whether PP adds useful information for predicting coronary heart disease (CHD) in the population-based Framingham Heart Study,Methods and Results-We studied 1924 men and women between 50 and 79 years of age at baseline with no clinical evidence of CHD and not taking antihypertensive drug therapy. Cox regression, adjusted for age, sex, and other risk factors, was used to assess the relations between blood pressure components and CHD risk over a 20-year follow-up. The association with CHD risk was positive for SEP, DBP, and PP, considering each pressure individually; of the 3, PP yielded the largest chi(2) statistic. When SEP and DBP were jointly entered into the multivariable model, the association with CHD risk was positive for SEP (HR, 1.22; 95% CI, 1.15 to 1.30) and negative for DBP (HR, 0.86; 95% CI, 0.75 to 0.98). Four subgroups were defined according to SEP levels (