An Environmental influences on Child Health Outcomes viewpoint of data analysis centers for collaborative study designs.
An Environmental influences on Child Health Outcomes viewpoint of data analysis centers for collaborative study designs.
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DOI：
10.1097/mop.0000000000000602
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发表时间：
2018-04
影响因子：
3.6
通讯作者：
Parker CB
中科院分区：
文献类型：
--
作者：
Jacobson LP;Lau B;Catellier D;Parker CB
高度复杂的协作研究设计汇集并扩展了现有研究，例如环境对儿童健康结果的影响 (ECHO) 计划，需要具有资源和专业知识的数据分析中心 (DAC) 来创建一个安全的环境来容纳和分析共享数据，协调和构建用于不同目的的共享数据，并应用适当和创新的设计和分析方法。 DAC 与队列研究人员合作，必须确保 ECHO 范围内的队列分析结果得到适当解释和可重复。了解对 ECHO 做出贡献的群体对于开发协作环境和无偏见地最佳分析数据的方法至关重要。我们进一步描述了 ECHO 范围的队列元数据目录的开发、ECHO 范围的队列数据平台的架构以及促进早期生产力的分析方法。 ECHO DAC 建立了一个用于传输和存储 ECHO 队列数据和信息的安全环境，并启动了促进富有成效的合作的流程。了解 ECHO DAC 的职责和资产将有助于克服在启动这项复杂的 ECHO 范围队列合作研究时遇到的沟通和信任挑战。
A highly complex collaborative study design that pools and extends existing studies, such as the Environmental influences on Child Health Outcomes (ECHO) Program, requires a Data Analysis Center (DAC) with resources and expertise to create a secure environment for housing and analyzing the shared data, harmonize and structure the shared data for different purposes, and apply appropriate and innovative designs and analytic methods. The DAC, in partnership with cohort investigators, must ensure that results from ECHO-wide cohort analyses are appropriately interpreted and reproducible. Understanding the cohorts contributing to ECHO is critical for developing a collaborative environment and the methods to best analyze the data without bias. We further describe the development of the ECHO-wide cohort Metadata Catalog, the architecture of the ECHO-wide cohort data platform, and analytical approaches to facilitate early productivity. The ECHO DAC has established a secure environment for the transfer and storage of ECHO cohort data and information, and initiated processes to promote productive collaborations. Understanding the ECHO DAC responsibilities and assets will help to overcome communication and trust challenges encountered in the initiation of this complex ECHO-wide cohort collaborative research study.