Serological evidence of ebolavirus infection in bats, China.
Serological evidence of ebolavirus infection in bats, China.
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DOI：
10.1186/1743-422x-9-236
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发表时间：
2012-10-13
期刊：
影响因子：
4.8
通讯作者：
Shi Z
中科院分区：
文献类型：
--
作者：
Yuan J;Zhang Y;Li J;Zhang Y;Wang LF;Shi Z
丝状病毒科的埃博拉病毒属目前由五个种组成。除莱斯顿埃博拉病毒外，所有物种均已在非洲发现并引起严重的人类疾病。蝙蝠被认为是埃博拉病毒的宿主。在菲律宾发现的莱斯顿埃博拉病毒是迄今为止在亚洲发现的唯一埃博拉病毒。目前尚不清楚这种病毒是否在中国流行。在这项研究中，我们利用重组核衣壳蛋白建立了埃博拉病毒的酶联免疫吸附试验（ELISA），并对中国蝙蝠群体进行了病毒的血清监测。结果显示，843份蝙蝠血清样本中有32份存在埃博拉病毒抗体，16份样本中有10份经western blot分析进一步证实。据我们所知，这是中国首例丝状病毒感染报告。
The genus Ebolavirus of the family Filoviridae currently consists of five species. All species, with the exception of Reston ebolavirus, have been found in Africa and caused severe human diseases. Bats have been implicated as reservoirs for ebolavirus. Reston ebolavirus, discovered in the Philippines, is the only ebolavirus species identified in Asia to date. Whether this virus is prevalent in China is unknown. In this study, we developed an enzyme linked immunosorbent assay (ELISA) for ebolavirus using the recombinant nucleocapsid protein and performed sero-surveillance for the virus among Chinese bat populations. Our results revealed the presence of antibodies to ebolavirus in 32 of 843 bat sera samples and 10 of 16 were further confirmed by western blot analysis. To our knowledge, this is the first report of any filovirus infection in China.