Review Devil's tools: SARS-CoV-2 antagonists against innate immunity.
Review Devil's tools: SARS-CoV-2 antagonists against innate immunity.
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DOI：
10.1016/j.crviro.2021.100013
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Hai R
中科院分区：
文献类型：
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作者：
Xu D;Biswal M;Neal A;Hai R
2019年前所未有的冠状病毒大流行（COVID-19）是由严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）引起的。与其他冠状病毒一样，为了建立其感染，SARS-CoV-2需要克服先天干扰素（IFN）反应，这是宿主防御的第一道防线。SARS-CoV-2还开发了复杂的拮抗方法，涉及几乎所有的编码病毒蛋白。在这里，我们总结了我们目前对这些不同病毒因子及其在抑制IFN反应中的作用的了解。其中一些是SARS-CoV使用的保守的IFN逃避策略;另一些是SARS-CoV-2仅采用的新对策。填补理解这些潜在机制的空白将为应用IFN治疗SARS-CoV-2感染提供理论指导。
The unprecedented Coronavirus pandemic of 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like other coronaviruses, to establish its infection, SARS-CoV-2 is required to overcome the innate interferon (IFN) response, which is the first line of host defense. SARS-CoV-2 has also developed complex antagonism approaches involving almost all its encoding viral proteins. Here, we summarize our current understanding of these different viral factors and their roles in suppressing IFN responses. Some of them are conserved IFN evasion strategies used by SARS-CoV; others are novel countermeasures only employed by SARS-CoV-2. The filling of gaps in understanding these underlying mechanisms will provide rationale guidance for applying IFN treatment against SARS-CoV-2 infection.