Proton magnetic resonance spectroscopy (MRS) in on-line game addiction.
Proton magnetic resonance spectroscopy (MRS) in on-line game addiction.
复制标题
在线游戏成瘾中的质子磁共振光谱（MRS）。
DOI：
10.1016/j.jpsychires.2014.07.007
复制
发表时间：
2014-11
影响因子：
4.8
通讯作者：
Renshaw PF
中科院分区：
文献类型：
--
作者：
Han DH;Lee YS;Shi X;Renshaw PF
最近的脑成像研究表明，额叶和颞叶皮层都是介导网络成瘾症状的重要候选区域。我们假设，赤字的前额叶和颞叶皮质功能的在线游戏成瘾（PGA）的患者将反映在N-乙酰天冬氨酸（NAA）和细胞溶质，胆碱化合物（Cho）的水平下降。研究招募了73名年轻PGA和38名年龄和性别匹配的健康对照受试者。使用3.0T MRI扫描仪获得结构MR和1H MRS数据。体素依次放置在右额叶皮层和右内侧颞叶皮层。在右侧额叶皮层，PGA组的NAA水平低于健康对照组。在内侧颞叶皮层，PGA参与者的Cho水平低于健康对照组。PGA的YIAS评分和持续反应与右额叶NAA水平呈负相关。PGA队列的Beck抑郁量表（BDI）评分与右颞叶Cho水平呈负相关。据我们所知，这是第一项针对在线游戏成瘾者的MRS研究。虽然，在目前的研究中，与在线游戏成瘾的主题是免费的精神共病，与在线游戏成瘾的患者出现共享的特点，ADHD和MDD的额叶和颞叶皮层的神经化学变化。
Recent brain imaging studies suggested that both the frontal and temporal cortices are important candidate areas for mediating the symptoms of internet addiction. We hypothesized that deficits of prefrontal and temporal cortical function in patients with on-line game addiction (PGA) would be reflected in decreased levels of N-acetyl aspartate (NAA) and cytosolic, choline containing compound (Cho). Seventy three young PGA and 38 age and sex matched healthy control subjects were recruited in the study. Structural MR and 1H MRS data were acquired using a 3.0 T MRI scanner. Voxels were sequentially placed in right frontal cortex and right medial temporal cortices. In the right frontal cortex, the levels of NAA in PGA were lower than those in healthy controls. In the medial temporal cortex, the levels of Cho in PGA participants were lower than those observed in healthy controls. The Young Internet Addiction Scale (YIAS) scores and perseverative responses in PGA were negatively correlated with the level of NAA in right frontal cortex. The Beck Depressive Inventory (BDI) scores in the PGA cohort were negatively correlated with Cho levels in the right temporal lobe. To the best of our knowledge, this is the first MRS study of individuals with on-line game addiction. Although, the subjects with on-line game addiction in the current study were free from psychiatric co-morbidity, patients with on-line game addiction appear to share characteristics with ADHD and MDD in terms of neurochemical changes in frontal and temporal cortices.