The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.
The Elephant in the Cell: Nuclear Mechanics and Mechanobiology.
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细胞中的大象：核力学和力学生物学。
DOI：
10.1115/1.4053797
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Szczesny,SpencerE
中科院分区：
文献类型：
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作者：
Jones,MichelleL;Dahl,KrisNoel;Lele,TanmayP;Conway,DanielE;Shenoy,Vivek;Ghosh,Soham;Szczesny,SpencerE
2021年夏季生物力学，生物工程和生物运输会议（SB3C）以题为“房间里的大象：核力学和机械生物学”的研讨会为特色。这次研讨会的目的是提供一个角度，从专家在该领域的核力学及其在机械生物学的作用，目前的理解。本文回顾了研讨会期间讨论的主要主题和问题，包括测量原子核力学性质的初始方法的历史背景和决定核力学的一级结构的分类，原子核的物理塑性，核骨架和细胞骨架连接体（LINC）的新作用在将细胞核与细胞质耦合以及驱动单个细胞和多细胞组件的行为方面的复杂性，以及目前用于研究基因表达和细胞信号传导机制的计算模型。正在进行的问题和争议，沿着有前途的未来方向，也进行了讨论。
The 2021 Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) featured a workshop titled “The Elephant in the Room: Nuclear Mechanics and Mechanobiology.” The goal of this workshop was to provide a perspective from experts in the field on the current understanding of nuclear mechanics and its role in mechanobiology. This paper reviews the major themes and questions discussed during the workshop, including historical context on the initial methods of measuring the mechanical properties of the nucleus and classifying the primary structures dictating nuclear mechanics, physical plasticity of the nucleus, the emerging role of the linker of nucleoskeleton and cytoskeleton (LINC) complex in coupling the nucleus to the cytoplasm and driving the behavior of individual cells and multicellular assemblies, and the computational models currently in use to investigate the mechanisms of gene expression and cell signaling. Ongoing questions and controversies, along with promising future directions, are also discussed.