Main Group Supramolecular Chemistry Led to Surprising New Directions in the Self-Assembly of Organic Macrocycles, Cages, and Cyclophanes
Main Group Supramolecular Chemistry Led to Surprising New Directions in the Self-Assembly of Organic Macrocycles, Cages, and Cyclophanes
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主族超分子化学为有机大环、笼和环芳的自组装带来了令人惊讶的新方向
DOI：
10.1055/a-1389-9498
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发表时间：
2021
期刊：
影响因子：
2
通讯作者：
Johnson, Darren W.
中科院分区：
文献类型：
--
作者：
Shear, Trevor A.;Johnson, Darren W.
环芳烷是一类令人钦佩的大环和笼状化合物，由于其高应变和不寻常的构象，常常表现出不寻常的性质。然而，新型复杂环芳烷的探索一直受到低产率、需要苛刻的反应条件和艰巨的纯化步骤的合成的阻碍。在这里，我们讨论了使用类金属定向自组装和动态共价化学来形成穴状配体的工作。然后将它们置于温和的条件下，以高产率产生离散的二硫化物、硫醚和烃大环化合物。然后使用“实验设计”从复杂的混合物中选择性合成目标大环化合物。1 简介2 隐窝到环烷3 功能化大环化合物4 “实验设计”靶向合成5 结论和展望
Cyclophanes are an admirable class of macrocyclic and cage compounds that often display unusual properties due to their high strain and unusual conformations. However, the exploration of new, complex cyclophanes has been encumbered by syntheses that can be low yielding, require harsh reaction conditions, and arduous purification steps. Herein, we discuss our work using metalloid-directed self-assembly and dynamic covalent chemistry to form cryptands. These were then subjected to mild conditions to produce discrete disulfide, thioether and hydrocarbon macrocycles in high yields. ‘Design of Experiments’ was then used to selectively synthesize targeted macrocycles from complex mixtures.1 Introduction2 Cryptands to Cyclophanes3 Functionalizable Macrocycles4 ‘Design of Experiments’ Targeted Synthesis5 Conclusions and Outlook
影响因子：
8.5
作者：
Prosun Bhattacharya;G. Jacks;S. Frisbie;Euan Smith;R. Naidu;Bibudhendra Sarkar
通讯作者：
Bibudhendra Sarkar
影响因子：
4.6
作者：
Cangelosi, Virginia M.;Carter, Timothy G.;Johnson, Darren W.
通讯作者：
Johnson, Darren W.