High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial
High-flow nasal cannula oxygen therapy and hypoxia during gastroscopy with propofol sedation: a randomized multicenter clinical trial
复制标题
丙泊酚镇静胃镜检查期间高流量鼻插管氧疗和缺氧：随机多中心临床试验
DOI：
10.1016/j.gie.2019.06.033
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发表时间：
2019-10-01
影响因子：
7.7
通讯作者：
Su, Diansan
中科院分区：
文献类型：
--
作者：
Lin, Yuxuan;Zhang, Xiaoqing;Su, Diansan
背景和目的：低氧是镇静剂胃镜检查最常见的不良事件之一，可导致严重后果。此前还没有发现预防缺氧的方法。高流量鼻腔插管支持性氧疗提供高达60 L/分钟的加温和加湿氧气。由于其能够改善呼吸功能和良好的耐受性，我们旨在评价高频NC支持性氧疗预防异丙酚镇静胃镜检查患者缺氧的有效性和安全性。方法：采用多中心、前瞻性、随机、单盲、随机、对照的方法，选择2017年11月至2018年2月在3个中心接受常规胃镜检查并由麻醉师提供异丙酚镇静的门诊患者1994例，随机分为两组：鼻插管组(氧气量为2 L/分钟)和高频氮化组(氧气量为30-60 L/分钟)。主要结果是低氧的发生率。结果：HFNC支持性氧疗降低了缺氧率(75%
Background and Aims: Hypoxia is one of the most frequent adverse events with sedated GI endoscopy and can lead to serious consequences. No modalities have been found previously to prevent hypoxia. High-flow nasal cannula (HFNC) supportive oxygen therapy provides heated and humidified oxygen up to 60 L/minute. Because of its ability to improve respiratory function and good tolerance, we aimed to evaluate the validity and safety of HFNC supportive oxygen therapy in preventing the incidence of hypoxia in patients undergoing gastroscopy with propofol sedation.Methods: In a multicenter, prospective randomized single-blinded study, 1994 outpatients undergoing routine gastroscopy with propofol sedation provided by an anesthesiologist were randomized into 2 groups: the nasal cannula group (O-2 [2 L/minute] was supplied via an HFNC) and the HFNC group (O-2 [30-60 L/minute] was supplied via an HFNC) at 3 centers from November 2017 to February 2018. The primary outcome was the incidence of hypoxia. Other adverse events were also recorded.Results: HFNC supportive oxygen therapy decreased the incidence of hypoxia (75%