Development of human fetal skin transplanted to the nude mouse.
Development of human fetal skin transplanted to the nude mouse.
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DOI：
10.1111/1523-1747.ep12284423
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发表时间：
1989-12
期刊：
影响因子：
--
通讯作者：
A. Lane;G. Scott;K. Day
中科院分区：
文献类型：
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作者：
A. Lane;G. Scott;K. Day
将35块人胎皮（HFS）移植物移植至裸鼠7 ~ 70 d，并通过64次活检进行组织学评价。移植时移植物的估计胎龄（EGA）范围为8至19周。通过评估表皮、真皮和附属物的发育来评估移植胎儿皮肤的成熟程度。在裸鼠体内，HFS表现出表皮分层和成熟的进展。真皮深度增加，增加了纤维血管间质和脂肪组织。附属物表现出内陷、分化和器官发生的进展。皮下移植物与子宫内移植物的HFS发展速度相同。移植物移植到裸鼠体表并暴露在空气中，显示出加速发育。我们得出结论，裸鼠移植HFS是维持和改变HFS成熟的有效体内模型。
Thirty-five human fetal skin (HFS) grafts were transplanted to nude mice for 7 to 70 d and evaluated histologically with 64 biopsies. The estimated gestational ages (EGA) of the grafts at the time of the transplantation ranged from 8 to 19 weeks. The maturation of the engrafted fetal skin was evaluated by assessing epidermal, dermal, and appendage development. Within the nude mouse, the HFS demonstrated progression in stratification and maturation of the epidermis. The dermis increased in depth, adding fibrovascular stroma and adipose tissue. The appendages demonstrated invagination, differentiation, and progression of organogenesis. Subcutaneously placed grafts showed the same rate of HFS development as HFS in utero. The grafts transplanted to the surface of the nude mice and exposed to air demonstrated an acceleration of development. We conclude that HFS transplanted to the nude mouse is an effective in vivo model for maintaining and altering HFS maturation.