Microstructural and biomechanical alterations of the human aorta as a function of age and location
Microstructural and biomechanical alterations of the human aorta as a function of age and location
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DOI：
10.1007/s10237-010-0209-7
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发表时间：
2010-12-01
影响因子：
3.5
通讯作者：
Vande Geest, Jonathan
中科院分区：
文献类型：
--
作者：
Haskett, Darren;Johnson, Gregory;Vande Geest, Jonathan
虽然已知主动脉随着位置和年龄而变硬，但对倾斜知之甚少：控制这些改变的潜在机制。本研究旨在探讨人主动脉各向异性生物力学行为与细胞外基质微观结构的关系，并量化其随位置和年龄的变化。从31条尸检供体主动脉（3天至93岁）的5个部位（上行n = 33，足弓n = 38，下行n = 54，肾上n = 52，腹部n = 30）共采集标本207例。为了得到各向异性刚度和柔顺性的定量生物力学终点，每个标本都进行了平面双轴测试。利用小角光散射（SALS）技术对同一样品进行了光纤定向和光纤定向程度的定量测量。随着年龄的增长，周围和轴向硬化发生，从主动脉近端到远端增加，腹部区域比其他所有区域更僵硬(p
While it is known that the aorta stiffens with location and age, little is known about tilt: underlying mechanisms that govern these alterations. The purpose of this study was to investigate the relationship between the anisotropic biomechanical behavior and extracellular matrix microstructure of the human aorta and quantify how each changes with location and age. A total of 207 specimens were harvested from 5 locations (ascending n = 33, arch n = 38, descending n = 54, suprarenal n = 52, and abdominal n = 30) of 31 autopsy donor aortas (aged 3 days to 93 year;). Each specimen underwent planar biaxial testing in order to derive quantitative biomechanical endpoints of anisotropic stiffness and compliance. Quantitative measures of fiber alignment and degree of fiber alignment were also generated on the same samples using a small-angle light scattering (SALS) technique. Circumferential and axial stiffening occurred with age and increased from the proximal to distal aorta, and the abdominal region was found to be more stiff than all others (p