Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses.
Chiba study of Mother and Children's Health (C-MACH): cohort study with omics analyses.
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DOI：
10.1136/bmjopen-2015-010531
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发表时间：
2016-01-29
期刊：
影响因子：
2.9
通讯作者：
Chiba study of Mother and Children's Health Group
中科院分区：
文献类型：
--
作者：
Sakurai K;Miyaso H;Eguchi A;Matsuno Y;Yamamoto M;Todaka E;Fukuoka H;Hata A;Mori C;Chiba study of Mother and Children's Health Group
最近的流行病学研究表明，胎儿期至幼儿期的环境因素可能影响成年后患非传染性疾病的风险。这被称为健康和疾病的发展起源（DOHaD）概念。千叶妇幼健康研究（C-MACH）是一项基于DOHaD假说的出生队列研究，涉及多组学分析。本研究旨在探讨遗传和环境因素，特别是胎儿环境和出生后生活环境对儿童健康的影响，并确定这些影响的潜在生物标志物。C-MACH由三个基于医院的队列组成。研究参与者是妊娠<13周的孕妇。 在三家医院之一接受检查的妇女得到了关于这项研究的解释。参与者同意完成问卷调查，并收集和储存生物和房屋/环境样本。为参与者提供唯一的研究编号。所有数据和生物标本将分别保存在千叶大学预防医学中心和千叶大学预防医学中心生物库中。433名妇女同意参加。在这些妇女中，376名妇女在妊娠早期完成了问卷调查。平均年龄为32.5（4.4）岁。平均体重指数（BMI）为21.1（3.0）kg/m2。怀孕前，72.3%的女性BMI为18.5-24.9 kg/m2。 在怀孕早期，5.0%的参与者吸烟。主要结局是过敏、肥胖、内分泌和代谢紊乱以及发育障碍。将评估基因组水平、代谢组水平、脐带DNA甲基化（表观基因组）、肠道微生物群和环境化学品暴露变量。我们将分析结果与分析变量之间的关系。
Recent epidemiological studies have shown that environmental factors during the fetal period to early childhood might affect the risk of non-communicable diseases in adulthood. This is referred to as the developmental origins of health and disease (DOHaD) concept. The Chiba study of Mother and Children's Health (C-MACH) is a birth cohort study based on the DOHaD hypothesis and involves multiomics analysis. This study aims to explore the effects of genetic and environmental factors—particularly the fetal environment and postbirth living environment—on children's health, and to identify potential biomarkers for these effects. The C-MACH consists of three hospital-based cohorts. The study participants are pregnant women at <13 weeks gestation. Women who underwent an examination in one of the three hospitals received an explanation of the study. The participants consented to completing questionnaire surveys and the collection and storage of biological and house/environmental samples. Participants were provided unique study numbers. All of the data and biological specimens will be stored in the Chiba University Center for Preventive Medical Sciences and Chiba University Center for Preventive Medical Sciences BioBank, respectively. Consent to participate was obtained from 433 women. Of these women, 376 women completed questionnaires in the early gestational period. The mean age was 32.5 (4.4) years. The mean body mass index (BMI) was 21.1 (3.0) kg/m2. Before pregnancy, 72.3% of the women had a BMI of 18.5–24.9 kg/m2. During early pregnancy, 5.0% of the participants smoked. Primary outcomes are allergy, obesity, endocrine and metabolic disorders, and developmental disorders. Genome-level, metabolome-level, umbilical cord DNA methylation (epigenome), gut microbiota and environmental chemical exposure variables will be evaluated. We will analyse the relationships between the outcomes and analytical variables.