Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
Association between circulating irisin levels and the promotion of insulin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients
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DOI：
10.1016/j.metabol.2013.12.007
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发表时间：
2014-04-01
影响因子：
9.8
通讯作者：
Casanueva, Felipe F.
中科院分区：
文献类型：
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作者：
Crujeiras, Ana B.;Angeles Zulet, M.;Casanueva, Felipe F.
Objective.体重恢复与胰岛素抵抗的促进有关。新发现的肌因子irisin，被认为参与胰岛素敏感性的管理，可能在这一过程中发挥作用。本研究旨在探讨鸢尾素与体重恢复引起的胰岛素敏感性降低之间的关系。根据胰岛素抵抗的稳态模型评估（HOMA-IR），在136名肥胖患者中评估胰岛素敏感性，这些患者遵循8周的低热量饮食（减少30%的能量消耗）以减轻体重，并在治疗后4个月或6个月重新评估。在基线（T0）、饮食终点（T1）和随访期后（T2），对初始研究患者的子队列（n = 73）中的鸢尾素血浆水平以及瘦素、脂联素、生长素释放肽和TNF-α水平进行定量。在成功的饮食干预减肥后，50%的患者在随访期间恢复了体重，被归类为胰岛素抵抗（HOMA-IR >= 2.5），而只有25%的患者保持了体重减轻（p = 0.018）。重要的是，除了研究充分的激素瘦素和脂联素，鸢尾素血浆水平与胰岛素抵抗的几个危险因素有统计学相关性。事实上，在随访期间胰岛素抵抗风险的增加与基线时的高鸢尾素水平有关（比值比= 4.2; p = 0.039）。循环中的鸢尾素可预测与体重恢复相关的胰岛素抵抗。因此，鸢尾素可以作为一种适应性反应分泌，以抵消过度肥胖对葡萄糖稳态的有害影响。(C)2014爱思唯尔公司All rights reserved.
Objective. Weight regain is associated with the promotion of insulin resistance. The newly discovered myokine irisin, which was proposed to be involved in the management of insulin sensitivity, could play a role in this process. This study aimed to investigate the association between irisin and reduced insulin sensitivity induced by weight regain.Materials/Methods. Insulin sensitivity was evaluated according to the homeostasis model assessment of insulin resistance (HOMA-IR) in 136 obese patients who followed an eight-week hypocaloric diet (30% reduced energy expenditure) to lose weight and was re-evaluated four or six months after treatment. Irisin plasma levels, as well as the levels of leptin, adiponectin, ghrelin and TNF-alpha, were quantified in a sub-cohort (n = 73) from the initially studied patients at baseline (T0), at the diet endpoint (T1) and after the follow-up period (T2).Results. After a successful dietary intervention to lose weight, 50% of the patients who regained the lost weight during the follow-up period were categorized as insulin resistant (HOMA-IR >= 2.5) compared with only 25% of patients who maintained the weight loss (p = 0.018). Importantly, in addition to the well-studied hormones leptin and adiponectin, irisin plasma levels were statistically associated with several risk factors for insulin resistance. Indeed, the increased risk of insulin resistance during the follow-up period was related to high irisin levels at baseline (odds ratio = 4.2; p = 0.039).Conclusions. Circulating irisin predicts the insulin resistance onset in association with weight regain. Therefore, irisin could be secreted as an adaptive response to counteract the deleterious effect of excess adiposity on glucose homeostasis. (C) 2014 Elsevier Inc. All rights reserved.