Brain alcohol detectability in human subjects with and without a paternal history of alcoholism
Brain alcohol detectability in human subjects with and without a paternal history of alcoholism
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DOI：
10.15288/jsa.2004.65.16
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Mello, NK
中科院分区：
文献类型：
--
作者：
Chiu, TM;Mendelson, JH;Mello, NK
目的：本研究探讨了父亲酗酒史对人类受试者大脑酒精明显可检测性的推定影响。方法：使用质子磁共振光谱成像在含有壳核的脑体素（2 x 2 x 2 cm）中测定两组男性的脑与血液乙醇比率。这些男性是轻度饮酒者，具有阳性（n = 8）或阴性（n = 8）父亲酒精中毒史，并给予0.8 g/kg体重的酒精剂量。结果：两组脑内酒精检出率均小于100%。两组的脑/血乙醇比率无显著差异（p = 0.37）。然而，对酒精极端影响和醉酒程度（“醉酒程度”）的主观评估与父亲酗酒史高度相关，父亲酗酒史阴性的组报告的醉酒感觉明显更强烈。结论：对现有文献证据和本研究中获得的数据的回顾表明，通过磁共振光谱成像的脑酒精检测率低于100%。父亲病史阳性和父亲病史阴性的男性之间的脑酒精检测能力没有显着差异。然而，两组之间主观高度评价量表评分的差异表明了遗传对酒精主观反应的重要性。
Objective: This study examined the putative effects of a paternal history of alcoholism on the apparent detectability of brain alcohol in human subjects. Method: Brain to blood ethanol ratios in two cohorts of men were determined, using proton magnetic resonance spectroscopic imaging in a brain voxel (2 x 2 x 2 cm) containing the putamen. The men were light drinkers with a positive (n = 8) or a negative (n = 8) paternal history of alcoholism and were given an alcohol dose of 0.8 g/kg body weight. Results: In both groups, brain alcohol detectability was less than 100%. No significant difference (p = .37) was found in the brain/blood ethanol ratios of the two groups. However, subjective assessments of feeling the extreme effects of alcohol and the ex-tent of intoxication ("how drunk") were highly correlated with a paternal history of alcoholism, with the paternal history negative group reporting significantly more intense feelings of intoxication. Conclusions: A review of existing literature evidence and data obtained in this study indicate that brain alcohol detectability via magnetic resonance spectroscopic imaging is less than 100%. There were no significant differences in brain alcohol detectability between paternal history positive and paternal history negative men. Differences in the Subjective High Assessment Scale ratings between the two groups, however, indicate the importance of a genetic influence on the subjective response to alcohol.