EFFECTS OF SCH-23390 AND SULPIRIDE ON THE REINFORCED RESPONDING OF THE YOUNG-RAT
EFFECTS OF SCH-23390 AND SULPIRIDE ON THE REINFORCED RESPONDING OF THE YOUNG-RAT
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DOI：
10.1037/0735-7044.105.5.744
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发表时间：
1991-10-01
影响因子：
1.9
通讯作者：
CRAWFORD, CA
中科院分区：
文献类型：
--
作者：
MCDOUGALL, SA;NONNEMAN, AJ;CRAWFORD, CA
在阻断多巴胺D1和D2受体系统后，评估17日龄大鼠幼仔的强化反应。 训练幼鼠穿越一条笔直的小巷以获得乳头附着奖励，然后注射不同剂量的舒必利（D2拮抗剂）、SCH 23390（D1拮抗剂）或舒必利和SCH 23390的组合。 然后在强化和消退试验中将药物处理的幼鼠的接近性能与溶剂处理的幼鼠进行比较。 SCH 23390（而非舒必利）抑制了幼仔的食欲接近反应。 在消退试验期间，SCH 23390给药幼仔的反应潜伏期长于溶剂给药幼仔。 “最佳得分”数据表明，SCH 23390主要影响奖励过程，而不是运动能力。 最重要的是，SCH 23390对强化反应的影响被舒必利增强，这表明D1和D2受体系统都参与了奖励过程。
Reinforced responding of 17-day-old rat pups was assessed after blockade of dopamine D1 and D2 receptor systems. Rat pups were trained to traverse a straight alley for nipple attachment reward and then injected with various doses of either sulpiride (D2 antagonist), SCH 23390 (D1 antagonist), or a combination of sulpiride and SCH 23390. The approach performance of drug-treated pups was then compared with vehicle-treated pups on both reinforcement and extinction trials. SCH 23390, but not sulpiride, depressed the appetitive approach responding of the pups. During extinction testing, SCH 23390-treated pups had longer response latencies than pups given vehicle. "Best score" data suggested that SCH 23390 primarily affected reward processes and not motor capability. Most important, the effects of SCH 23390 on reinforced responding were potentiated by sulpiride, suggesting that both the D1 and D2 receptor systems are involved in reward processes.