The Mothers, Infants, and Lactation Quality (MILQ) Study: A Multi-Center Collaboration.
The Mothers, Infants, and Lactation Quality (MILQ) Study: A Multi-Center Collaboration.
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DOI：
10.1093/cdn/nzab116
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发表时间：
2021-10
影响因子：
4.8
通讯作者：
Moore SE
中科院分区：
文献类型：
--
作者：
Allen LH;Hampel D;Shahab-Ferdows S;Andersson M;Barros E;Doel AM;Eriksen KG;Christensen SH;Islam M;Kac G;Keya FK;Michaelsen KF;de Barros Mucci D;Njie F;Peerson JM;Moore SE
关于人乳营养素浓度的有效信息很少，特别是微量营养素（MN），并且在整个哺乳期内没有有效的参考值（RV）。在这项多中心合作研究中，将建立产后前8.5个月母乳营养素的RV。在妊娠晚期招募孟加拉国、巴西、丹麦和冈比亚（n = 250/研究中心）营养良好、未补充营养的女性。在3次访视（产后1-3.49、3.5-5.99、6.0-8.49个月）时，相同地收集母亲及其婴儿的乳汁、血液、唾液、尿液和粪便样品。牛奶分析包括常量营养素、选定的维生素、微量元素和矿物质、碘、代谢组学、氨基酸、人乳低聚糖和生物活性肽。我们测量牛奶体积;孕产妇和婴儿饮食、人体测量和发病率;婴儿发育、孕产妇基因组以及婴儿和孕产妇微生物组。RV将根据世卫组织儿童生长标准和共生-21项目的方法建造。本试验在clinical trials.gov注册为NCT 03254329。本文介绍了一项母乳成分国际研究的方案，该方案将使哺乳期间母乳营养素浓度参考值的构建成为可能。
Little valid information is available on human milk nutrient concentrations, especially for micronutrients (MNs), and there are no valid reference values (RVs) across lactation. In this multi-center collaborative study, RVs will be established for human milk nutrients across the first 8.5 mo postpartum. Well-nourished, unsupplemented women in Bangladesh, Brazil, Denmark, and The Gambia (n = 250/site) were recruited during the third trimester of pregnancy. Milk, blood, saliva, urine, and stool samples from mothers and their infants are collected identically at 3 visits (1–3.49, 3.5–5.99, 6.0–8.49 mo postpartum). Milk analyses include macronutrients, selected vitamins, trace elements and minerals, iodine, metabolomics, amino acids, human milk oligosaccharides, and bioactive peptides. We measure milk volume; maternal and infant diets, anthropometry, and morbidity; infant development, maternal genome, and the infant and maternal microbiome. RVs will be constructed based on methods for the WHO Child Growth Standards and the Intergrowth-21st Project. This trial was registered at clinical trials.gov as NCT03254329. This article describes the protocol for an international study of human milk composition that will enable the construction of reference values for milk nutrient concentrations during lactation.