Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair.
Extracellular Vesicles and the Application of System Biology and Computational Modeling in Cardiac Repair.
复制标题
细胞外囊泡以及系统生物学和计算建模在心脏修复中的应用。
DOI：
10.1161/circresaha.117.311215
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发表时间：
2018-07-06
影响因子：
20.1
通讯作者：
Kishore R
中科院分区：
文献类型：
--
作者：
Garikipati VNS;Shoja-Taheri F;Davis ME;Kishore R
最近的文献表明，细胞外小泡(EV)是正常生理和病理条件下细胞内通讯的主要驱动力，它由大多数细胞分泌，含有细胞特有的蛋白质、脂类和核酸。最近关于干细胞/祖细胞EVS作为模仿其亲代细胞功能的潜在治疗方式的证据是令人兴奋的，因为EVS可能被用作基于干细胞的治疗的替代品，该方案可能克服使用干细胞/祖细胞本身所确定的某些障碍。本文综述了EVS在心脏修复中的作用，重点介绍了干细胞/祖细胞来源的EVS在治疗中的应用，并讨论了EV治疗面临的挑战。
Recent literature suggests that extracellular vesicles (EV), secreted from most cells and containing cell specific cargo of proteins, lipids and nucleic acids are major driver of intracellular communication in normal physiology and pathological conditions. The recent evidence on stem/progenitor cell EVs as potential therapeutic modality mimicking their parental cell function is exciting since EVs could possibly be used as a surrogate for the stem cell based therapy and this regimen may overcome certain roadblocks identified with the use of stem/progenitor cell themselves. This review provides a comprehensive update on our understanding on the role of EVs in cardiac repair and emphasizes the applications of stem/progenitor cell derived EVs as therapeutics and discusses the current challenges associated with the EV therapy.