Validation of real-time continuous perfusion measurement.
Validation of real-time continuous perfusion measurement.
复制标题
实时连续灌注测量的验证。
DOI：
10.1007/bf02347053
复制
发表时间：
2000
影响因子：
3.2
通讯作者：
Bowman,HF
中科院分区：
文献类型：
--
作者：
Martin,GT;Bowman,HF
灌注，即组织中的血液在毛细血管水平上得到补充的速率，是热量、药物、氧气和营养物质输送的主要因素。虽然已经提出了许多测量技术，但大多数都不适合常规，连续和实时使用。一种微创探头，称为热扩散探头（TDP），它使用自加热热敏电阻连续和真实的时间测量绝对灌注，在低流量与微球技术进行了验证。在27只家兔中，从0到60 ml min-1100 g-1同时测量肝脏中的TDP。TDP灌注与微球相关性良好（R2=0.898），并且技术之间的一致性非常好，斜率接近1（0.921），截距接近0（0.566 ml min-1100 g-1）。两种技术之间的差异主要是由于与连续TDP灌注测量相比，周期性血流的微球“快照”的采样误差。连续地并且真实的时间地量化局部灌注的能力可能对诸如器官移植、神经外科、肿瘤学等许多临床领域中的患者管理具有深远的影响，其中灌注的定量知识是有价值的。
Perfusion, the rate at which blood in tissue is replenished at the capillary level, is a primary factor in the transport of heat, drugs, oxygen and nutrients. While there have been many measurement techniques proposed, most do not lend themselves to routine, continuous and real-time use. A minimally invasive probe, called the thermal diffusion probe (TDP), which uses a self-heated thermistor to measure absolute perfusion continuously and in real time, was validated at low flows with the microsphere technique. In 27 rabbits, simultaneous TDP measurements were made in liver from 0 to 60 ml min−1100 g−1. The TDP perfusion correlated well with the microspheres (R2=0.898) and the agreement between techniques is very good with a slope close to unity (0.921) and an intercept close to zero (0.566 ml min−1100 g−1). Variability between the two techniques was primarily due to the sampling error from the microsphere ‘snap shot’ of periodic blood flow when compared with the continuous TDP perfusion measurement. The ability to quantify local perfusion continuously and in real time may have a profound impact on patient management in a number of clinical areas such as organ transplantation, neurosurgery, oncology and others, in which quantitative knowledge of perfusion is of value.