D3 and D2 dopamine receptor agonists differentially modulate isolation-induced social-emotional reactivity in mice
D3 and D2 dopamine receptor agonists differentially modulate isolation-induced social-emotional reactivity in mice
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DOI：
10.1016/s0166-4328(00)00193-5
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发表时间：
2000-09-01
影响因子：
2.7
通讯作者：
Lewis, MH
中科院分区：
文献类型：
--
作者：
Gendreau, PL;Petitto, JM;Lewis, MH
在隔离住所后，小鼠通常对轻微的社会刺激表现出高度的情绪反应。根据紧张程度的不同，可以观察到在运动激活方面不同的攻击性、社交回避和各种防御行为(例如，冻结、逃跑)。以前的研究表明，D-2样多巴胺(DA)受体在特定形式的防御行为的中介中发挥着重要的作用，尽管是品系特有的。D-3受体是D-2样受体的亚型，在大脑边缘区域高度表达，因此，它们被假设为调节情绪行为。本研究考察了D-3受体激动剂7-OH-DPAT和PD128907对C57BL/6J和A/J小鼠社会情绪行为的影响。并与选择性D-2受体激动剂PNU91356A的作用进行了比较。所有三种DA激动剂都增加了非运动形式的防御行为(如僵硬、直立的防御姿势)。这些效应在低剂量C57BL/6J小鼠和较高剂量的A/J小鼠中观察到。只有D-3受体激动剂在较高剂量下有效地增加防御行为的运动形式(即逃脱、跳跃)。这些影响在C57BL/6J小鼠中比在A/J小鼠中更为明显。在静止和运动防御行为增加的同时，这两个品系的社会调查明显减少。攻击性品系C57BL/6J的攻击性行为也被取消。这些结果支持了以前的发现，并表明DA激动剂增强了防御行为和/或社会恐惧。他们还提出，D-3和D-2DA受体对社会-情绪反应性的表达有不同的调节作用，并表明了紧张在检测DA配体对情绪行为的影响方面的重要性。(C)2000 Elsevier Science B.V.保留所有权利。
Following isolation housing, mice typically exhibit heightened emotional reactivity to mild social stimulation. Aggression, social avoidance and a variety of defensive behaviors that differ in terms of motor activation (e.g. freezing, escape) can be observed depending on strain. previous studies suggested that D-2-like dopamine (DA) receptors play an important, albeit strain specific, role in the mediation of particular forms of defensive behavior. D-3 receptors are subtypes of D-2-like receptors that are highly expressed in limbic areas of the brain and, therefore, they have been hypothesized to mediate emotional behavior. This study examined the effects of the putative D-3 receptor agonists 7-OH-DPAT and PD128907 on social-emotional behavior in isolated C57BL/6J and A/J mice. These effects were compared with those of the selective D-2 receptor agonist PNU91356A. All three DA agonists increased non-locomotor forms of defensive behavior (e.g. freezing, upright defensive posture). These effects were observed at low doses ill C57BL/6J and at higher doses in A/J mice. Only the D-3 receptor agonists were effective in increasing locomotor forms of defensive behavior (i.e. escape, jump) at higher doses. These effects were more pronounced in C57BL/6J mice than A/J mice. The increases in stationary and locomotor defensive behavior were accompanied by marked reduction in social investigation in both the strains. Aggressive behavior was also abolished in the aggressive C57BL/6J strain. These results support previous findings and suggest that DA agonists potentiate defensive behavior and/or social fearfulness. They also suggest that D-3 and D-2 DA receptors differentially modulate the expression of social-emotional reactivity and indicate the importance of strain in examining the effects of DA ligands on emotional behavior. (C) 2000 Elsevier Science B.V. All rights reserved.