Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.
Xenograft and genetically engineered mouse model systems of osteosarcoma and Ewing's sarcoma: tumor models for cancer drug discovery.
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DOI：
10.1517/17460441.2013.817988
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发表时间：
2013-10
影响因子：
6.3
通讯作者：
Kolb EA
中科院分区：
文献类型：
--
作者：
Sampson VB;Kamara DF;Kolb EA
有> 75种组织学类型的实体瘤，分为两大类：骨肉瘤和软组织肉瘤。这些疾病在儿童中更为普遍，儿童肉瘤往往具有高度侵袭性和快速进展性。成年人的肉瘤可能会有一个更缓慢的过程，但侵袭性肿瘤也很常见。诊断时转移或治疗后复发的肉瘤，对目前的治疗方案仍然是难治的，总生存率很低。对于肉瘤患者，临床试验的一个主要焦点是确定针对恶性细胞特异性基因组或蛋白质组畸变的新的和更有效的治疗策略。理解靶向治疗潜力的关键是代表临床疾病并预测相关临床反应的疾病模型。在这篇文章中，作者讨论了小鼠异种移植模型和基因工程小鼠在癌症药物发现中的应用。作者提供了两种最常见的骨肉瘤模型：骨肉瘤（OS）和尤文氏肉瘤（ES）。预测一种新的抗癌药物是否会对OS和ES患者产生积极的治疗指数仍然是一个挑战。使用小鼠肉瘤模型来了解肿瘤对新治疗的反应机制是药物发现和这些疾病临床相关治疗策略开发过程中的重要一步。
There are > 75 histological types of solid tumors that are classified into two major groups: bone and soft-tissue sarcomas. These diseases are more prevalent in children, and pediatric sarcomas tend to be highly aggressive and rapidly progressive. Sarcomas in adults may follow a more indolent course, but aggressive tumors are also common. Sarcomas that are metastatic at diagnosis, or recurrent following therapy, remain refractory to current treatment options with dismal overall survival rates. A major focus of clinical trials, for patients with sarcoma, is to identify novel and more effective therapeutic strategies targeted to genomic or proteomic aberrations specific to the malignant cells. Critical to the understanding of the potential for targeted therapies are models of disease that are representative of clinical disease and predictive of relevant clinical responses. In this article, the authors discuss the use of mouse xenograft models and genetically engineered mice in cancer drug discovery. The authors provide a special focus on models for the two most common bone sarcomas: osteosarcoma (OS) and Ewing's sarcoma (ES). Predicting whether a new anticancer agent will have a positive therapeutic index in patients with OS and ES remains a challenge. The use of mouse sarcoma models for understanding the mechanisms involved in the response of tumors to new treatments is an important step in the process of drug discovery and the development of clinically relevant therapeutic strategies for these diseases.
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影响因子：
3.2
作者：
Houghton, Peter J.;Morton, Christopher L.;Gorlick, Richard;Kolb, E. Anders;Keir, Stephen T.;Reynolds, C. Patrick;Kang, Min H.;Maris, John M.;Wu, Jianrong;Smith, Malcolm A.
通讯作者：
Smith, Malcolm A.
DOI：
10.1073/pnas.0805462105
发表时间：
2008-08-19
影响因子：
11.1
作者：
Berman, Seth D.;Calo, Eliezer;Lees, Jacqueline A.
通讯作者：
Lees, Jacqueline A.
影响因子：
45.3
作者：
Fouladi, Maryam;Laningham, Fred;Furman, Wayne L.
通讯作者：
Furman, Wayne L.
影响因子：
50.5
作者：
Grignani, G.;Palmerini, E.;Aglietta, M.
通讯作者：
Aglietta, M.
影响因子：
3.7
作者：
Gisselsson, D;Pålsson, E;Dal Cin, P
通讯作者：
Dal Cin, P