Endometrial thickness as a predictor of pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection.
Endometrial thickness as a predictor of pregnancy after in-vitro fertilization but not after intracytoplasmic sperm injection.
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DOI：
10.1093/oxfordjournals.humrep.a019434
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发表时间：
1996-07
影响因子：
6.1
通讯作者：
Leonardo Rinaldi;Franco Lisi;Attuia Floccari;R. Lisi;Giampiero Pepe;Simon Fishel
中科院分区：
文献类型：
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作者：
Leonardo Rinaldi;Franco Lisi;Attuia Floccari;R. Lisi;Giampiero Pepe;Simon Fishel
对158例接受体外辅助生殖卵巢刺激的患者进行子宫内膜超声检查。对109例接受体外受精（IVF）治疗女性适应症的患者和49例接受卵胞浆内单精子注射（ICSI）治疗男性适应症的患者的子宫内膜厚度进行了评价。在人绒毛膜促性腺激素（HCG）给药当天，使用放置在子宫内膜-子宫肌层界面交界处的电子卡尺在冷冻图像上纵向扫描子宫，测量子宫内膜最大厚度。子宫内膜厚度>/=10 mm的病例被纳入A组; ICSI中子宫内膜厚度≥ 10 mm的病例比IVF患者更常见。IVF组A患者妊娠率（32/79; 41%）高于IVF组B患者（5/30; 17%）（P = 0.03），而ICSI组A患者妊娠率（13/42; 31%）与ICSI组B患者妊娠率（3/7; 43%）差异无统计学意义。因此，与ICSI患者相比，IVF患者中子宫内膜薄的比例更高;子宫内膜薄仅在女性不孕症（IVF）的情况下是妊娠的预后指标。在女性不孕症病例中，薄的子宫内膜可能反映了先前或当前的子宫病理学，而在男性不孕症的适应症中（即使用ICSI的病例），在没有任何相关子宫病理学的情况下，薄的子宫内膜的存在不是预测性的。
An ultrasonographic evaluation of the endometrium was performed in 158 patients undergoing ovarian stimulation for an in-vitro assisted reproduction programme. Endometrial thickness was evaluated in 109 patients undergoing in-vitro fertilization (IVF) for female indications and in 49 patients undergoing intracytoplasmic sperm injection (ICSI) for male indications. The maximal endometrial thickness was measured on the day of human chorionic gonadotrophin (HCG) administration by longitudinal scanning of the uterus on the frozen image using electronic callipers placed at the junction of the endometrium-myometrium interface at the level of the fundus. Cases in which the endometrial thickness was >/=10 mm were included in group A; cases in which the endometrial thickness was =10 mm was more frequent in ICSI than in IVF patients. The incidence of pregnancy was higher in IVF group A patients (32/79; 41%) than in IVF group B patients (5/30; 17%) (P = 0.03), whereas no significant difference was found between ICSI group A (13/42; 31%) and ICSI group B (3/7; 43%) patients. Thus, a higher percentage of IVF patients had thin endometrium when compared with ICSI patients; thin endometrium was a prognostic indicator of pregnancy only in the case of a female indication for infertility (IVF). A thin endometrium in cases of female infertility may reflect a previous or present uterine pathology, whereas in indications of male infertility (i.e. cases using ICSI), in the absence of any associated uterine pathology, the presence of a thin endometrium is not predictive.